About Mefeego® Pack
The best thing to do is to ensure contraception, but if you end up with an unwanted pregnancy, there is the option of an induced abortion.
Oak Clinic, Sumiyoshi performs abortions up to less than 12 weeks, using surgical and oral medication procedures.
We listen to the patient to determine which method to choose, and make recommendations based on the pregnancy week and the mother's health condition.
Mefeego® Pack is an oral abortion pill that enables early-term abortion by taking two medications (Mifepristone and Misoprostol) and must be administered at a prescribing medical facility under the supervision of a physician designated by the Maternal Protection Act.
At our hospital, we keep safety and confidentiality above all else in mind, and we listen to patients and make recommendations based on the number of weeks pregnant and the health status of the mother.
About the action of Mefeego® Pack
The Mefeego® Pack is an oral drug with two abortive actions:
- ・1 mifepristone tablet (1st tablet)
- ・4 misoprostol buccal tablets (2nd tablet)
contains two drugs.
It is intended for abortion for pregnant women who are 63 days (9 weeks and 0 day) or less pregnant and can be taken under the supervision of a physician designated under the Maternal Protection Act (hereinafter: designated physician).
Individual purchases cannot be made at pharmacies or online stores.Do not purchase or use the product even if it is sold by mail order or other means.
Although it was only approved in Japan in April 2023, it is the WHO-recommended abortion method and has been widely used around the world for more than 30 years.
About the effects of drugs
1st drug：Mifepristone
This medicine suppresses the action of the progesterone, which is necessary for the continuation of pregnancy.
2nd drug：Misoprostol
Misoprostol causes the
uterus to contract and expel the gestational sac.
Consultation schedule and cost
The consultation/hospitalization schedule/costs using Mefeego® Pack are as follows.
After hospitalization, it will be prescribed under the supervision of a designated doctor.
Mefeego® Pack consultation and hospitalization schedule
| ①Initial consultation and explanation | A pregnancy test will be performed and you will receive information about the oral contraceptive pill, Mefeego® Pack |
|---|
| ②Administration of the first drug | You will receive treatment as an outpatient at our hospital. |
|---|
| ③Administration of second drug | After arriving at the clinic at 8:30 a.m., 36-48 hours after the first dose, you will take 4 tablets of the second dose of Misoprostol under the confirmation of your assigned physician. |
|---|
| ④Post-dose examination |
If a gestational sac (liver-shaped lump) is expelled along with bleeding after prescribing 1 or 2 drugs, please notify the designated doctor. |
|---|
Cost of Mefeego® Pack
| Item | Tax excluded | Tax included | |
|---|---|---|---|
| Regular price | ¥130,000 | ¥143,000 | |
*1） If the second dose is taken on Saturday, there will be an additional cost of ¥50,000 (tax excluding).
*2） If the second dose is taken on a Sunday, there will be an additional charge of ¥100,000 (tax excluding).
*3） Painkillers, antibiotics, etc. will be charged separately.
*4） Prices are subject to change without notice. Please contact our staff for details.
Symptoms and safety of Mefeego® Pack administration
About bleeding
If you notice any abnormalities, contact the medical institution that prescribed this medicine.
Uterine bleeding occurs in all cases after receiving this drug and continues for a certain period of time.
In addition, severe uterine bleeding with symptoms such as syncope has been reported to occur in rare cases.
Because uterine bleeding may exacerbate anemia, those with severe anemia should always inform their designated physician.
Bleeding tends to increase from 0 to 4 hours before confirmation of fetal ejection, and often continues for some time after confirmation of fetal ejection.
Lower abdominal pain
It has been reported that lower abdominal pain occurs in almost all cases after administration.
Additionally, infections such as endometritis may occur(Frequency unknown).
Other Notes
If you have an intrauterine device (IUD) or IUS, remove it before administering this medicine.
For the time being, until the proper use of Mefeego Pack is established for trial use, in-hospital waiting is mandatory from the second drug (Misoprostol) administration until the fetus is expelled, whether in the hospital or as an outpatient.
If you are currently taking any medications or are breastfeeding, you may be affected by the medication, so please consult your doctor beforehand for instructions.
Individual purchases cannot be made at pharmacies or online stores.Do not purchase or use the product even if it is sold by mail order or other means.
Abortion success rate and adverse events due to Mefeego® Pack administration
Success rate of induced abortion in domestic phase Ⅲ trials
The success rate of induced abortion within 24 hours after administration of the second Mefeego® Pack tablet (misoprostol) is reported to be 93.3%. (Number of successful cases: 112/120 cases)
(Reference)
Ministry of Health, Labour and Welfare, "Proper Use, etc. of the So-Called Oral Abortion Pill 'Mefeego Pack'" Line Pharma KK, “Mefeego® Pack Patient Drug Guide”
Regarding the occurrence of adverse events and side effects in domestic phase Ⅲ trials
| Severe uterine bleeding | 0.8% |
| Lower abdominal pain | 30.0% |
| Vomiting | 20.8% |
| Infectious | Frequency unknown |
| Severe skin disorders | Frequency unknown |
| Anaphylactic shock | Frequency unknown |
Complication frequency of induced abortion surgery
| Complications | Frequency of occurrence*1 |
|---|---|
| Remnants and revision surgery | 0.27% |
| Hemorrhaging | 0.03% |
| Uterine perforation and injury | 0.02% |
| Shock | 0.01% |
| Severe infection | 0.004% |
(Reference) From the Health, Labor and Welfare Scientific Research Grant Research Report “Abortion Methods and Complications in Japan”
*1) Percentage of induced abortions performed in 2012
Complication rate in conventional abortion procedures (including aspiration surgery, curettage surgery, and both).
Based on the results of a survey of 108,148 induced abortions performed in 2012.
（Obstetrics and gynecology facilities nationwide with doctors designated by the Maternal Protection Act: 58.6% of 4,154 responses responded）
*Surgery includes both aspiration surgery (automatic and manual MVA) and curettage surgery.
The data show that uterine bleeding occurs more frequently with oral drug induced abortions than with surgically induced abortions.
If you are using an intrauterine device (IUD) or IUS, remove it before administering this medicine.
For the time being, until the proper use of MephigoPac is established for trial use, in-hospital waiting is mandatory from the second drug (Misoprostol) administration until the fetus is expelled, whether in the hospital or as an outpatient.
If you are currently taking any medications or are breastfeeding, you may be affected by the medication, so please consult your doctor beforehand for instructions.
Those who cannot receive treatment
If any of the following apply to you, you may not be able to receive medication or your medication may be restricted, so please consult your doctor.
- If you have had a history of hypersensitivity to any of the ingredients contained in this drug
- Previous hypersensitivity to prostaglandin E1 derivative preparations
- People with polyphyne syndrome
- If you are receiving systemic or inhaled corticosteroids, there is a concern that your condition may worsen or you may experience withdrawal symptoms due to decreased effectiveness of these drugs
- People with or suspected of having a bleeding disorder
- Those with severe liver damage
- Use of anticoagulants
- Use of antiplatelet agents
- Use of the following drugs that strongly or moderately induce the drug-metabolizing enzyme CYP3A
Rifampicin, Rifabutin, Carbamazepine, Phenytoin, Foods containing Hypericum perforatum, Phenobarbital, Bosentan, Efavirenz, Dabrafenib, Primidone, Sotorasib - Those using intrauterine contraceptives
In addition to the drugs listed above, there are other drugs that should be used with caution. Be sure to tell your designated doctor if you are taking any medications.
Other precautions
If an induced abortion is not achieved after administration of this drug, surgical procedures may be performed.
Before administration, Rh blood type will be confirmed, and if necessary, measures to prevent infection may be taken for Rh (D) negative patients.
Regarding reservations
Please call within our business hours to make a booking.
Please inquire before your visit as each facility may handle things differently.
Our Ginza location only handles infertility treatment.
English Help Desk
TEL:070-1820-0909
Email:english_help@oakclinic-group.com
[Reception time]
Monday-Sunday 09：00-17：00