Endometrial Receptivity Analysis(ERA) Guidance

What is ERA(Endometrial Receptivity Analysis)?

ERA is a test to determine at what point in time the endometrium is most receptive for a successful implantation.
It checks the genetic level, and whether or not the endometrium is receptive to implantation, on the day of the embryo transfer, when transferring a frozen-thawed blastocyst. Sometimes, even when the endometrium is purposely put in a possible condition for implantation after repeated cases of implantation failure, it is not optimal at a genetic level.

❈During the test cycle, there will be no transfers. We will only do the test.

Test Method

We will use the same medicine that is used in the hormone support cycle timed just like a thawed embryo transfer.

1. Thawed Embryo Transfer Cases

(1) Estrogen will be taken from Day 2 of menstruation.
(2) We will check the thickness of the endometrium around Day 12 of menstruation (those far away, may be omitted).
(3) Progesterone use will begin and on Day 5 of use, endometrial tissue sample will be taken and sent away for the test.

2. Natural Cycle Cases

After ovulation is confirmed, on the 5th day endometrial cell tissues will be collected and submitted for testing.

Test Results

2-3 weeks will be needed until the test results are ready.

子宮内膜着床能(ERA)検査の結果

Regarding Endometrial Tissue Retrieval

he procedure will take about 5 minutes. In most cases it will be done without anesthesia. It is not necessary to stop eating before this procedure. However, because there may be pain associated with the insertion of the curette, the procedure can be done under a local anesthetic.

子宮内膜組織採取

If there is pain at the time of tissue sampling, it is the kind of pain expected during menstruation and will only be for an instant. For patients who have low tolerance to pain, the dispensing of pain killers will be considered by patient request through consultation.
Additionally it is very rare, but a general anesthesia (intravenous) is sometimes requested. It is possible to handle this request, but because fasting and pretreatment is necessary, please let us know beforehand if you strongly want this treatment. A separate fee is needed for anesthesia and pretreatment.

Endometrial Receptivity Analysis (ERA) Costs

For ERA, there is a deposit (prepayment.) The final cost will be tallied at the end of the process, and the bill will be settled. (If it is less than the prepayment, a refund is provided. If it is more, the patient must pay the difference.)

Treatment Location Patients having IVF done at our clinic All other Patients
Number of samples
collected in a cycle
1 specimen 2 specimens 1 specimen 2 specimens
Number of Inspections 1st Cycle Re-examination for precise results. 1st Cycle Re-examination for precise results.
ERA Costs ¥117,880 ¥95,070 ¥212,950 ¥217,880 ¥195,070 ¥312,950
Prepayment ¥130,000 ¥130,000 ¥230,000 ¥230,000 ¥230,000 ¥330,000
  • Costs of medicine, ultrasound, other tests, basic consultation are done at a separate cost.
  • Displayed costs are all without tax.
  • Costs are subject to change without notice.

Starting from September 1st, 2020, ERA cycles require prepayment to be made prior to the first day of the cycle.
For details, please see here >>

【About Retesting Due to Inadequate Sample 】

As for the ERA test, sometimes it will be necessary to retest due to an inadequate sample because it is very difficult to collect a good sample.
If a retest is necessary due to inadequate sample the test fee will be free, but please understand that we will still have to charge for the medicine.

Endometrial Receptivity Analysis(ERA) Test Related Page