{"id":1462,"date":"2024-10-08T19:47:26","date_gmt":"2024-10-08T10:47:26","guid":{"rendered":"https:\/\/www.oakclinic-group.com\/wp\/brca\/"},"modified":"2024-12-06T12:03:42","modified_gmt":"2024-12-06T03:03:42","slug":"brca","status":"publish","type":"page","link":"https:\/\/www.oakclinic-group.com\/zh\/gynecology\/brca\/","title":{"rendered":"\u5987\u79d1\u68c0\u67e5\uff08\u5987\u4ea7\u79d1\uff09\u6307\u5bfc"},"content":{"rendered":"
\r\n
\r\n
\r\n

\r\n \u5168\u9762\u764c\u75c7\u6613\u611f\u6027\u68c0\u6d4b\r\n \r\n \uff08BRCA 1\uff0cBRCA 2\u57fa\u56e0\u68c0\u6d4b\uff09\r\n <\/span>\r\n<\/h1>\r\n\r\n
\r\n

\u4f4f\u5409<\/a><\/span> \u6885\u7530\r\n<\/a><\/span> \u94f6\u5ea7<\/a><\/span><\/p>\r\n<\/div>\r\n\r\n

\r\n

\r\n \u7db2\u7f57\u6027\u764c\u75c7\u654f\u611f\u6027\u68c0\u6d4b\uff08BRCA1\u3001BRCA2\u57fa\u56e0\u68c0\u6d4b\uff09\r\n <\/h2>\r\n

\r\n BRCA1\u3001BRCA2\u57fa\u56e0\u68c0\u6d4b\u662f\u4ec0\u4e48\uff1f\r\n <\/h3>\r\n

\r\n \u57fa\u56e0\u548c\u7ec8\u8eab\u98ce\u9669\r\n <\/h4>\r\n
\r\n

\r\n \u5206\u6790\u768446\u4e2a\u57fa\u56e0\u88ab\u5206\u4e3a\u4e09\u4e2a\u4e3b\u8981\u7ec4\uff1a\u9ad8\u98ce\u9669\u3001\u4e2d\u98ce\u9669\u548c\u65b0\u98ce\u9669\u3002\r\n <\/p>\r\n

\r\n \u30fb\u9ad8\u98ce\u9669\u57fa\u56e0\r\n <\/p>\r\n

\r\n \u5728\u5177\u6709\u9ad8\u98ce\u9669\u57fa\u56e0\u7684\u4eba\u4e2d\uff0c\u4e0e\u4e00\u822c\u4eba\u7fa4\u76f8\u6bd4\uff0c\u98ce\u9669\u589e\u52a0\u4e864\u500d\u4ee5\u4e0a\u3002\r\n \r\n \u5177\u6709\u9ad8\u98ce\u9669\u57fa\u56e0\u7684\u4eba\u53ef\u80fd\u5728\u5e74\u8f7b\u65f6\u60a3\u4e0a\u764c\u75c7\u6216\u80bf\u7624\uff0c\u6216\u8005\u7ec8\u8eab\u60a3\u6709\u591a\u79cd\u764c\u75c7\u7684\u98ce\u9669\u66f4\u9ad8\u3002\r\n \r\n \u9ad8\u98ce\u9669\u57fa\u56e0\u5305\u62ecBRCA1\u3001BRCA2\uff08BRCA\u76f8\u5173\u4e73\u817a\u764c\u6216\u5375\u5de2\u764c\u7efc\u5408\u5f81\uff09; CDH1\uff08\u9057\u4f20\u6027\u5f25\u6f2b\u6027\u80c3\u764c\u7efc\u5408\u5f81\uff09; EPCAM\u3001MLH1\u3001MSH2\u3001MSH6\u3001PMS2\uff08\u6797\u5947\u7efc\u5408\u5f81\uff09; PALB2; PTEN\uff08\u5305\u62ec\u79d1\u767b\u7efc\u5408\u5f81\u7684PTEN\u80bf\u7624\u7efc\u5408\u5f81\uff09; TP53\uff08Li-Fraumeni\u7efc\u5408\u5f81\uff09\u3002\r\n <\/p>\r\n

\r\n \u56fe1\uff1a\u5982\u679c\u5177\u6709\u9ad8\u98ce\u9669\u57fa\u56e0\u7684\u4eba\u5177\u6709\u81f4\u75c5\u6027\u7a81\u53d8\uff0c\u5219\u60a3\u4e73\u817a\u764c\u548c\u5375\u5de2\u764c\u7684\u7ec8\u8eab\u98ce\u9669\r\n <\/p>\r\n

\r\n\"#\"\r\n<\/p>\r\n

\r\n\r\n \u6839\u636e\u6700\u65b0\u7684\u764c\u75c7\u6cbb\u7597\u548c\u764c\u75c7\u4fe1\u606f\u7684\u53c2\u8003\u8d44\u6599\"BRCA1\u3001BRCA2\u57fa\u56e0\uff1a\u764c\u75c7\u98ce\u9669\u548c\u57fa\u56e0\u68c0\u6d4b\"\r\n <\/a>\r\n<\/p>\r\n

\r\n \u30fb\u4e2d\u5ea6\u98ce\u9669\u57fa\u56e0\r\n <\/p>\r\n

\r\n \u643a\u5e26\u4e2d\u5ea6\u98ce\u9669\u57fa\u56e0\u7684\u4eba\u4e0e\u666e\u901a\u4eba\u7fa4\u76f8\u6bd4\uff0c\u5728\u5176\u4e00\u751f\u4e2d\u60a3\u4e0a\u764c\u75c7\u7684\u98ce\u9669\u589e\u52a02\u500d\u81f34\u500d\u3002\r\n <\/p>\r\n

\r\n \u30fb\u65b0\u98ce\u9669\u57fa\u56e0\r\n <\/p>\r\n

\r\n \u5b58\u5728\u4e0e\u764c\u75c7\u98ce\u9669\u76f8\u5173\u7684\u65b0\u98ce\u9669\u57fa\u56e0\uff0c\u5c3d\u7ba1\u5c1a\u672a\u5145\u5206\u7814\u7a76\uff0c\u4f46\u5df2\u7ecf\u88ab\u9274\u5b9a\u51fa\u6765\u3002\r\n <\/p>\r\n

\r\n \u7db2\u7f85\u6027\u764c\u57fa\u56e0\u9762\u677f\u68c0\u6d4b\u8fd8\u5305\u62ec\u88681\u4e2d\u7684\u9057\u4f20\u6027\u4e73\u817a\u764c\u548c\u5375\u5de2\u764c\u76f8\u5173\u57fa\u56e0\uff0c\u4ee5\u53ca\u4ee5\u4e0b\u57fa\u56e0\uff1aAPC\u3001AXIN2\u3001BMPR1A\u3001CDK4\u3001CDKN2A\u3001MUTYH\u3001POLD1\u3001POLE\u3001SCG5 \/ GREM1\u3001SMAD4\u3001STK11\u3001VHL\u3002\r\n <\/p>\r\n

\r\n \u88681\uff1a\u4e0e\u9057\u4f20\u6027\u4e73\u817a\u764c\u548c\u5375\u5de2\u764c\u76f8\u5173\u7684\u57fa\u56e0\u7684\u764c\uff08\u80bf\u7624\uff09\u7684\u7ec8\u8eab\u98ce\u9669\r\n <\/p>\r\n

\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n
\r\n<\/th>\r\n\r\n \u9057\u4f20\u57fa\u56e0\r\n <\/th>\r\n\r\n \u764c\u75c7\uff08\u80bf\u7624\uff09\u7684\u751f\u6daf\u98ce\u9669\r\n <\/th>\r\n<\/tr>\r\n
\r\n \u9ad8\u98ce\u9669\u9057\u4f20\u57fa\u56e0\r\n <\/td>\r\n\r\n BRCA1\r\n <\/td>\r\n\r\n \u5973\u6027\u4e73\u623f\uff0857-87%\uff09\u3001\u5375\u5de3\uff0824-54%\uff09\u3001\u524d\u7acb\u817a\u3001\u7537\u6027\u4e73\u623f\u3001\u80f0\u81df\u3001\u5375\u7ba1\u3001\u539f\u767c\u6027\u8179\u819c\u3001\u5b50\u5bae\u5167\u819c\r\n <\/td>\r\n<\/tr>\r\n
\r\n BRCA2\r\n <\/td>\r\n\r\n \u5973\u6027\u4e73\u623f\uff0841-84%\uff09\u3001\u524d\u7acb\u817a\uff0820-34%\uff09\u3001\u5375\u5de3\uff0811-27%\uff09\u3001\u80f0\u81df\uff085-7%\uff09\u3001\u7537\u6027\u4e73\u623f\uff084-7%\uff09\u3001\u9ed1\u8272\u7d20\u7624\u3001\u5375\u7ba1\u3001\u539f\u767c\u6027\u8179\u819c\u3001\u5b50\u5bae\u5167\u819c\r\n <\/td>\r\n<\/tr>\r\n
\r\n CDH1\r\n <\/td>\r\n\r\n \u80c3\u764c\uff0840-83%\uff09\u3001\u5973\u6027\u4e73\u623f\uff0839-52%\uff09\u3001\u7d50\u8178\r\n <\/td>\r\n<\/tr>\r\n
\r\n

\r\n EPCAM,\r\n \r\n MLH1,\r\n \r\n MSH2,\r\n \r\n MSH6,\r\n <\/p>\r\n PMS2\r\n <\/td>\r\n

\r\n

\r\n \u7d50\u8178\u76f4\u8178\uff0811-80%\uff09\u3001\u5b50\u5bae\u5167\u819c\uff0812-61%\uff09\u3001\u5375\u5de3\uff081-24%\uff09\u3001\u80c3\uff08\uff1c1-20%\uff09\u3001\u5c3f\u8def\uff081-10%\uff09\u3001\u80f0\u81df\u3001\u81bd\u9053\u3001\u5c0f\u8178\u3001\u8166\u3001\u76ae\u8102\u817a\u7624\r\n <\/p>\r\n \uff08\u816b\u7624\u7bc4\u570d\u662f\u6797\u5947\u75c7\u5019\u7fa4\u7684\u4ee3\u8868\uff1a\u5c0d\u65bcMSH6\u3001PMS2\u3001EPCAM\u81f4\u75c5\u6027\u57fa\u56e0\u8b8a\u7570\u9ad4\u8207\u7279\u5b9a\u764c\u75c7\u7684\u95dc\u806f\u6027\u6578\u64da\u6709\u9650\uff09\r\n <\/td>\r\n<\/tr>\r\n

\r\n PALB2\r\n <\/td>\r\n\r\n \u5973\u6027\u4e73\u623f\uff0825-58%\uff09\u3001\u7537\u6027\u4e73\u623f\u3001\u80f0\u81df\u3001\u5375\u5de3\r\n <\/td>\r\n<\/tr>\r\n
\r\n PTEN\r\n <\/td>\r\n\r\n \u5973\u6027\u4e73\u623f\uff0825-85%\uff09\u3001\u7532\u72c0\u817a\uff083-38%\uff09\u3001\u5b50\u5bae\u5167\u819c\uff085-28%\uff09\u3001\u7d50\u8178\u3001\u814e\u81df\u3001\u9ed1\u8272\u7d20\u7624\u3001\u80c3\u8178\u606f\u8089\r\n <\/td>\r\n<\/tr>\r\n
\r\n TP53\r\n <\/td>\r\n\r\n

\r\n \u5973\u6027\u4e73\u623f\u3001\u9aa8\u8089\u7624\u548c\u8edf\u7d44\u7e54\u3001\u8166\u3001\u60e1\u6027\u816b\u7624\u3001\u814e\u4e0a\u817a\u76ae\u8cea\u764c\u7b49\uff1b\r\n <\/p>\r\n \u764c\u75c7\u7684\u7e3d\u9ad4\u98a8\u96aa\uff1a\u5973\u6027\u5e7e\u4e4e\u662f100\uff05\uff0c\u7537\u6027\u70ba73\uff05\r\n <\/td>\r\n<\/tr>\r\n

\r\n \u4e2d\u5ea6\u98ce\u9669\u9057\u4f20\u57fa\u56e0\r\n <\/td>\r\n\r\n ATM\r\n <\/td>\r\n\r\n \u5973\u6027\u4e73\u623f\u3001\u7ed3\u80a0\u3001\u80f0\u817a\r\n <\/td>\r\n<\/tr>\r\n
\r\n BRIP1\r\n <\/td>\r\n\r\n \u5375\u5de2\u3001\u5973\u6027\u4e73\u623f\r\n <\/td>\r\n<\/tr>\r\n
\r\n CHEK2\r\n <\/td>\r\n\r\n \u5973\u6027\u4e73\u623f\u3001\u7537\u6027\u4e73\u623f\u3001\u7ed3\u80a0\u3001\u524d\u5217\u817a\u3001\u7532\u72b6\u817a\u3001\u5b50\u5bab\u5185\u819c\u3001\u5375\u5de2\r\n <\/td>\r\n<\/tr>\r\n
\r\n RAD51C\r\n <\/td>\r\n\r\n \u5375\u5de2\u3001\u5973\u6027\u4e73\u623f\r\n <\/td>\r\n<\/tr>\r\n
\r\n RAD51D\r\n <\/td>\r\n\r\n \u5375\u5de2\u3001\u5973\u6027\u4e73\u623f\r\n <\/td>\r\n<\/tr>\r\n
\r\n \u65b0\u98ce\u9669\u9057\u4f20\u57fa\u56e0\r\n <\/td>\r\n\r\n BARD1\r\n <\/td>\r\n\r\n \u5973\u6027\u4e73\u623f\u3001\u5375\u5de2\r\n <\/td>\r\n<\/tr>\r\n
\r\n FANCC\r\n <\/td>\r\n\r\n \u5973\u6027\u4e73\u623f\r\n <\/td>\r\n<\/tr>\r\n
\r\n NBN\r\n <\/td>\r\n\r\n \u5973\u6027\u4e73\u623f\u3001\u9ed1\u8272\u7d20\u7624\u3001\u975e\u4f55\u6770\u91d1\u6dcb\u5df4\u7624\r\n <\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<\/div>\r\n
\r\n

\r\n \u6837\u672c\u63d0\u4ea4\r\n <\/h3>\r\n

\r\n \u68c0\u6d4b\u662f\u901a\u8fc7\u91c7\u96c6\u53e3\u8154\u7c98\u819c\u4e2d\u7684DNA\u6765\u8fdb\u884c\u7684\u3002\r\n \r\n \u8981\u63a5\u53d7\u68c0\u6d4b\uff0c\u9700\u8981\u63d0\u4ea4\u95ee\u8bca\u8868\u3001\u540c\u610f\u4e66\u548c\u7533\u8bf7\u4e66\u3002\r\n <\/p>\r\n<\/div>\r\n

\r\n

\r\n \u7ed3\u679c\r\n <\/h3>\r\n
\r\n

\r\n \u7ed3\u679c\u5c06\u5728\u5927\u7ea62\u81f34\u5468\u5185\u5f97\u51fa\u3002\u68c0\u6d4b\u7ed3\u679c\u5206\u4e3a\u4ee5\u4e0b4\u4e2a\u7c7b\u522b\uff1a\r\n <\/p>\r\n

    \r\n
  1. \r\n \u9633\u6027\uff08\u5b58\u5728\u81f4\u75c5\u7a81\u53d8\uff09\r\n <\/li>\r\n
  2. \r\n \u81f4\u75c5\u7a81\u53d8\u6000\u7591\r\n <\/li>\r\n
  3. \r\n \u9634\u6027\uff08\u65e0\u81f4\u75c5\u7a81\u53d8\uff09\r\n <\/li>\r\n
  4. \r\n \u610f\u4e49\u4e0d\u660e\u7684\u7a81\u53d8\r\n <\/li>\r\n<\/ol>\r\n<\/div>\r\n<\/div>\r\n
    \r\n

    \r\n \u57fa\u4e8e\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c\u7684\u533b\u7597\u7ba1\u7406\r\n <\/h3>\r\n

    \r\n \u6839\u636e\u7ed3\u679c\uff0c\u5c06\u63d0\u51fa\u65e9\u671f\u53d1\u73b0\u6216\u964d\u4f4e\u98ce\u9669\u7684\u533b\u7597\u7ba1\u7406\u3002\r\n \r\n \u533b\u7597\u7ba1\u7406\u5305\u62ec\u5f3a\u5316\u7b5b\u67e5\u3001\u964d\u4f4e\u98ce\u9669\u7684\u624b\u672f\uff0c\u6709\u65f6\u4e5f\u5305\u62ec\u836f\u7269\u6cbb\u7597\u4ee5\u964d\u4f4e\u98ce\u9669\u3002\r\n \r\n \u63a8\u8350\u7684\u7b5b\u67e5\u68c0\u6d4b\u5305\u62ecMRI\u3001\u4e73\u817aX\u7ebf\u6444\u5f71\u3001\u8d85\u58f0\u68c0\u67e5\u3001\u5185\u7aa5\u955c\u68c0\u67e5\u3001\u6d3b\u68c0\u7b49\u3002\r\n <\/p>\r\n<\/div>\r\n

    \r\n

    \r\n \u68c0\u6d4b\u7684\u9650\u5236\r\n <\/h3>\r\n

    \r\n \u5373\u4f7f\u8fdb\u884c\u4e86\u5168\u9762\u764c\u75c7\u654f\u611f\u6027\u68c0\u6d4b\uff0c\u4e5f\u5b58\u5728\u5404\u79cd\u7c7b\u578b\u7684\u764c\u75c7\uff0c\u5e76\u4e14\u5728\u5c06\u6765\u53ef\u80fd\u4f1a\u60a3\u764c\u75c7\u7684\u98ce\u9669\u3002\r\n \r\n \u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u8ba4\u4e3a\u764c\u75c7\u98ce\u9669\u4e0d\u4f1a\u6bd4\u6d4b\u8bd5\u7ed3\u679c\u4e3a\u9634\u6027\u7684\u4e00\u822c\u4eba\u7fa4\u66f4\u9ad8\u3002\r\n \r\n \u5bf9\u4e8e\u4e2d\u7b49\u98ce\u9669\u6216\u65b0\u98ce\u9669\u57fa\u56e0\u7684\u63cf\u8ff0\uff0c\u7ed3\u679c\u7684\u89e3\u91ca\u53ef\u80fd\u4f1a\u53d7\u5230\u9650\u5236\u3002\r\n \r\n \u5373\u4f7f\u7ed3\u679c\u4e3a\u9634\u6027\uff0c\u4e5f\u53ef\u80fd\u5b58\u5728\u4e0e\u5bb6\u65cf\u6027\u80bf\u7624\u6709\u5173\u7684\u5176\u4ed6\u57fa\u56e0\u6216\u672a\u68c0\u6d4b\u5230\u7684\u57fa\u56e0\u533a\u57df\u3002\r\n \r\n \u9057\u4f20\u4e13\u5bb6\u6216\u5176\u4ed6\u533b\u7597\u63d0\u4f9b\u8005\u53ef\u80fd\u4f1a\u5224\u65ad\u9700\u8981\u8fdb\u4e00\u6b65\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u3002\r\n <\/p>\r\n<\/div>\r\n

    \r\n

    \r\n \u68c0\u6d4b\u7684\u597d\u5904\r\n <\/h3>\r\n

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    \r\n

    \r\n \u8d39\u7528\r\n <\/h3>\r\n

    \r\n \u00a5240,000\uff08\u4e0d\u542b\u7a0e\uff09\r\n <\/p>\r\n

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