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Vol.14 (Issue date:2017-5-15)

Medical Society Information

The Oak Group actively participates in academic societies held in Japan and overseas in order to obtain the latest information and techniques on infertility treatment and to present the research results at this hospital.

69th Annual Meeting of the Japanese Society of Obstetrics and Gynecology

69th Annual Meeting of the Japanese Society of Obstetrics and Gynecology: April 13-16, 2017

[Case report: The occurrence of multinucleated embryos after intra-cytoplasmic sperm injection (ICSI) treatment may be prevented by the administration of prednisolone]

Case report: Development of multinucleated fertilized eggs after intracytoplasmic sperm injection may be prevented by administration of prednisolone.

(Taguchi S, Funabiki M, Hayashi T, Tada Y, Iwaki Y, Karita M, Nakamura Y)

In-Hospital Study

A briefing session was held on the subcutaneous injection syringe of the hCG preparation used in the egg collection cycle : March 1st, 2017

Explanation session on the subcutaneous injection syringe for hCG medication used in the egg retrieval cycle

A briefing session was held on a syringe for self-injection of the hCG preparation used as a trigger for ovulation induction.
It is a product with a good track record overseas, and was approved by the Ministry of Health, Labor and Welfare in Japan in September last year.

With the introduction of this product, you will be able to perform the injections you had made at your home the night before the egg collection.
Since the drug is pre-loaded in a syringe with a needle, it is a product that is easy to operate.

At the Oak Association, we are introducing it on a trial basis at the Oak Clinic, Sumiyoshi.

From the Oak Group Blog (Excerpt)

Malformations of Sperm

When explaining the results of a semen test in an outpatient setting, we will talk about the normal rate morphology of sperm along with the amount of semen, the number of sperm, and the motility of sperm.
The normal morphology rate of sperm is simply the rate of malformed sperm.
According to WHO standards, it used to be 15% or more, but recently it has been changed to the diagnosis that the normal morphology rate of sperm is normal up to 5%.


We are often asked if malformed sperm cause birth defects.
However, it isn’t the case.
Malformed sperm are sperm morphological abnormalities that do not really represent chromosomal abnormalities associated with fetal abnormalities.
However, if the child is a boy, the child may inherit azoospermia because it inherits the traits of the father.
Of course, when selecting sperm by microinsemination, etc., the normal form is selected, but even in the case of malformed sperm, childbirth with a healthy baby is possible.
A paper has been published to support this.
Hum Reprod. 2016 Jun;31(6):1164-72. doi: 10.1093/humrep/dew083. Epub 2016 Apr 19. *Patients with multiple morphological abnormalities of the sperm flagella due to DNAH1 mutations have a good prognosis following intracytoplasmic sperm injection.*


Hum Reprod. 2016 Jun;31(6):1164-72. doi: 10.1093/humrep/dew083. Epub 2016 Apr 19. *Patients with multiple morphological abnormalities of the sperm flagella due to DNAH1 mutations have a good prognosis following intracytoplasmic sperm injection.*


Regarding sperm morphological abnormalities, there are head abnormalities, neck abnormalities, and tail abnormalities, but this paper examines sperm flagella (tail) abnormalities.
Some chromosomal abnormalities were significantly higher, but many were not significantly different.
DNA damage was also not higher than in normal sperm, and overall fertilization, pregnancy and parturition rates were 70.8%, 50.0% and 37.5%, with no significant statistical differences compared to normal control groups.


Letters from Patients

It was difficult for me to have a baby, so I moved from one hospital to another, and in the seventh year of my marriage, I was given the first in vitro fertilization at your hospital, and when the child was one year old, I started treatment for the second.

It took 7 years to have the first child, and there was a great deal of financial anxiety.
Now my baby is 2 years 8 months and 7 months old.
I was busy with every day and realized that raising children was difficult, but I am so happy that I cannot imagine it during treatment.
I feel that meeting you is the beginning of my happiness. Thank you very much.

Infertility News

Ministry of Health, Labor and Welfare reviews guidelines to ban genome editing of fertilized eggs(4/12)

On the 12th, the Ministry of Health, Labor and Welfare will ban clinical research to return fertilized human eggs that have cured the diseased gene to the uterus using a new technology "genome editing" that can freely modify the genome (all genetic information) of the organism.
We have begun to consider reviewing the treatment guidelines.
Current guidelines prohibit modification by introducing another gene into a fertilized egg. However, there is no provision regarding genome editing that modifies by administering proteins or the like.
Last year, the government's Bioethics Study Group approved the editing of genomes for fertilized human eggs only for basic research for the treatment of diseases for which there is no cure.
However, clinical application of transplanting fertilized eggs into the female body is prohibited.
The Ministry of Health, Labor and Welfare envisions broadening the definition of gene therapy to ban all alterations in fertilized eggs that lead to childbirth.

In vitro fertilization reaches a new maximum, 420,000 in 2015, 1 in 20 babies(9/11)

The Japan Society of Obstetrics and Gynecology has summarized the results of a survey on in vitro fertilization conducted in Japan in 2015 by the 11th.
In vitro fertilization performed in 2015 reached a record high in both treatments and births, with 424,151 in vitro fertilizations, and it was reported that 51,001 were born, which is about 1 in 20 babies.

Reproduction of embryo growth in mice = Stem cell combination culture-UK University(3/3)

A research team at Cambridge University in the United Kingdom has developed a technology that almost reproduces the growth process by collecting two types of stem cells from embryos in which fertilized mouse eggs have divided and proliferated and culturing them in combination in a petri dish.
Published in the electronic version of the American scientific journal.
If realized in humans, it is expected to be useful for investigating the embryonic abnormalities that cause miscarriage.
In this technique, embryonic stem cells (ES cells) that change into various cells and trophoblast stem cells (TS cells) that form the placenta are combined and cultured to grow into "ETS embryos".
Since there are no stem cells that form the yolk sac that nourishes the embryo, there is no concern that it will grow to a fetus.
If human ETS embryos are produced, research to investigate the growth process is expected to proceed.

Staff Introduction

Medical Office(Oak Clinic, Umeda) Mirai Kinoshita

Medical Office(Oak Clinic, Umeda)Mirai Kinoshita

Special skill Massage
Motto Walk a mile in someone else’s shoes
Hobbies Eating at delicious restaurants
Message We strive to ensure that everyone can go to the hospital with peace of mind and receive medical examinations smoothly.
We also support our medical office staff so that you can get pregnant as soon as possible.
If you have any questions, please feel free to contact the front desk.