Recurrent Miscarriage, Habitual Miscarriages


Regarding Immunotherapy


In 1981 with a habitual miscarriage of unknown causes, the immunotherapy of the husband’s lymphocytes to be inoculated into the wife inside the skin had been reported.   Inside the human body, there are provided mechanisms of immunity to try to exclude others that are different from it.  Usually, it is the case that the immunity of the pregnant mother’s body to the other so called fetus is decreasing, but with the repeated miscarriage the immunotherapy of transferring the lymphocytes that are regarded an unsatisfactory immunological pregnancy maintenance mechanism was done for a long time.  However, even though there was a report of a successful example, in 1999 it was shown to have a result being invalid by the test (REMIS study) for clinical research (Ober C. et al., Lancet. 1999 Jul 31;354(9176):365-9.).  Also, in the US, it is an equivalent medical practice, and because there is also a report that there is a serious risk of infection and graft-versus-host reaction, (Katz I et al., Fertil Steril. 1992 Apr;57(4):927-9.), for purposes other than research, it is recommended not to do it.


In regards to the immunosuppressive therapy used for the intravenous administration of immunoglobulin therapy and prednisolone (corticosteroids), in the same way it could not acknowledge the results by comparative testing.  (Porter TF, et al. Immunotherapy for recurrent miscarriage. Cochrane Database of Systematic Reviews 2006, Issue 2. Art. No.: CD000112. DOI: 10.1002/14651858.CD000112.pub2.) (Rai R and Regan L, Lancet. 2006 Aug 12;368(9535):601-11).


Based on these, presently we are not doing immunotherapy.