Pioneer of infertility treatment. Covering the needs of infertility from various tests 
to IVF/ICSI’s Advanced Reproductive Technologies.

The Aim of Next Treatment








Freeze all embryos








Change the type of hormones



G-CSF Intrauterine Injection Method

Uterine Lumen Administration of Granulocyte Colony‐Stimulating Factor Formula for Thin Endometrium in  the Thawed Embryo Transfer Cycle

Uterine Lumen Administration of Granulocyte Colony‐Stimulating Factor Formula for Thin Endometrium in the Thawed Embryo Transfer Cycle It is known that an endometrium thickness of over 7mm is needed in order to heighten the possibility of pregnancy by IVF/Embryo Implant. In the hormone support and thawed embryo transfer cycle, in order for the endometrium to have this thickness, we will have you take estrogen after the cycle starts.

However, about 1% of patients even after using estrogen like this, the endometrium will still not reach the appropriate thickness and the patient will be forced to postpone the embryo transfer.

Up until this point a number of formulas have been tested that should have improved a thin endometrium but it cannot be said that there was any sufficient rise in the effects.

2~9 days before the embryo transfer, it has been reported by the American Society of Reproductive Medicine in Society magazine that a drug called, “Granulocyte Colony‐Stimulating Factor” (G‐CSF), administered once to the uterine cavity, will improve endometrium thickness and significantly improve the pregnancy rate. (Gleicher N et al., Fertility and Sterility 2011; 95: 2123.e13-e17)。

The drug G-CSF is approved (the granulocyte increasing effect) and is used to treat medical conditions widely by injection. We will administer it to patients who have met the following requirements;


・Patients who have history of embryo transfers being postponed based on the endometrium not reaching the appropriate thickness of 7mm repeatedly whilst using estrogen in the thawed embryo transfer cycle

・Patients who have given their consent on this form after understanding the meaning and necessity of this treatment




For first time clinic visit patients
English Service

At Oak Clinic we are accepting first time consultations by email for patients who are considering to visit us for the first time.


If it is a serious or urgent matter related to treatment please call us between: 
Monday thru Friday 10:00~16:00, and Saturday 10:00~13:00.
Telephone: 070 1820 0909

For all other inquiries please email us.




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Oak Medical Group has been from the time we opened, supporting the many issues of women's health, building performance and trust, and not only here in Osaka, but centering in Kansai we are receiving patients from across Japan.
Especially with our infertility treatment, we are widely covering the various tests to IVF/ICSI's Advanced Reproductive Technologies.  Depending on the cause of the infertility, we are handling the treatment of each patient one by one.  If you have some concerns, please don't hesitate to consult with us.