{"id":1263,"date":"2024-10-08T19:46:43","date_gmt":"2024-10-08T10:46:43","guid":{"rendered":"https:\/\/www.oakclinic-group.com\/wp\/nmn_drip\/"},"modified":"2025-01-24T09:58:54","modified_gmt":"2025-01-24T00:58:54","slug":"nmn_drip","status":"publish","type":"page","link":"https:\/\/www.oakclinic-group.com\/en\/infertility\/nmn_drip\/","title":{"rendered":"NMN drip therapy"},"content":{"rendered":"<div class=\"section-dept__container\">\r\n<div class=\"section-dept__first_content\">\r\n<section class=\"section-dept__content01\">\r\n<h1 class=\"section-dept__content01_title\">\r\n     NMN drip therapy\r\n     <br\/>\r\n<span style=\"font-size:0.85em;\">\r\n      \u03b2-Nicotinamide Mononucleotide\r\n     <\/span>\r\n<\/h1>\r\n<!-- \u5404\u30af\u30ea\u30cb\u30c3\u30af -->\r\n<div class=\"float_right pt10\">\r\n<p><span class=\"text_frame2\"><a href=\"https:\/\/www.oakclinic-group.com\/en\/sumiyoshi\/\">Sumiyoshi<\/a><\/span> <span class=\"text_frame2\"><a href=\"https:\/\/www.oakclinic-group.com\/en\/umeda_ladys\/\">Umeda<\/a><\/span> <span class=\"text_frame2\"><a href=\"https:\/\/www.oakclinic-group.com\/en\/ginza_ladys\/\">Ginza<\/a><\/span><\/p>\r\n<\/div>\r\n<p style=\"clear: both;\">\r\n<\/p>\r\n<!-- \u5404\u30af\u30ea\u30cb\u30c3\u30af \u3053\u3053\u307e\u3067 -->\r\n<div class=\"section-dept__content01_text mt-50\">\r\n<div class=\"section-dept__content02_text\">\r\n<div class=\"ivf_icsi_cap\">\r\n<div class=\"ivf_text02 mt20\">\r\n<!--<p>NMN drip therapy (\u03b2-Nicotinamide Mononucleotide) is a next-generation anti-aging therapy whose rejuvenating effects were discovered in research at Harvard Medical School.<\/p>-->\r\n<ul class=\"list_type1 bold\">\r\n<li>\r\n          Activation of sirtuin (longevity) genes, reviving youthfulness\r\n         <\/li>\r\n<li>\r\n          Body fat percentage decreases, muscle percentage increases\r\n         <\/li>\r\n<li>\r\n          Restores physical strength\r\n         <\/li>\r\n<li>\r\n          I can sleep soundly\r\n         <\/li>\r\n<li>\r\n          Estrogen rise\r\n         <\/li>\r\n<li>\r\n          Breathing easier during exercise\r\n         <\/li>\r\n<li>\r\n          Improves skin texture, firmness, and whitening\r\n         <\/li>\r\n<li>\r\n          Mitochondrial activation\r\n         <\/li>\r\n<li>\r\n          clear one's head\r\n         <\/li>\r\n<li>\r\n          Improves thinking and concentration\r\n         <\/li>\r\n<li>\r\n          Metabolism increases\r\n         <\/li>\r\n<\/ul>\r\n<\/div>\r\n<figure class=\"ivf00 mt20\">\r\n<img decoding=\"async\" alt=\"NMN drip therapy\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/infertility\/nmn_image.png\"\/>\r\n<\/figure>\r\n<div class=\"ivf pb10\">\r\n<p class=\"headline\">\r\n<a href=\"#activation\" style=\"font-size: 0.7em;\">\r\n          What is sirtuin (longevity) gene activation by NMN drip therapy?\r\n          <img decoding=\"async\" alt=\"btn\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/headline_circle_btn.png\"\/>\r\n<\/a>\r\n<\/p>\r\n<\/div>\r\n<div class=\"ivf pb10\">\r\n<p class=\"headline\">\r\n<a href=\"#about_nmn\">\r\n          What is NMN?\r\n          <img decoding=\"async\" alt=\"btn\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/headline_circle_btn.png\"\/>\r\n<\/a>\r\n<\/p>\r\n<\/div>\r\n<div class=\"ivf pb10\">\r\n<p class=\"headline\">\r\n<a href=\"#disease\">\r\n          Diseases with potential therapeutic effects\r\n          <img decoding=\"async\" alt=\"btn\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/headline_circle_btn.png\"\/>\r\n<\/a>\r\n<\/p>\r\n<\/div>\r\n<div class=\"ivf pb10\">\r\n<p class=\"headline\">\r\n<a href=\"#treatment\">\r\n          Method of treatment\r\n          <img decoding=\"async\" alt=\"btn\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/headline_circle_btn.png\"\/>\r\n<\/a>\r\n<\/p>\r\n<\/div>\r\n<div class=\"ivf pb10\">\r\n<p class=\"headline\">\r\n<a href=\"#side_effects\">\r\n          Contraindications and side effects of NMN drip therapy\r\n          <img decoding=\"async\" alt=\"btn\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/headline_circle_btn.png\"\/>\r\n<\/a>\r\n<\/p>\r\n<\/div>\r\n<div class=\"ivf pb10\">\r\n<p class=\"headline\">\r\n<a href=\"#nmn_fees\">\r\n          NMN drip therapy cost\r\n          <img decoding=\"async\" alt=\"btn\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/headline_circle_btn.png\"\/>\r\n<\/a>\r\n<\/p>\r\n<\/div>\r\n<div class=\"ivf pb10\">\r\n<p class=\"headline\">\r\n<a href=\"#quality\">\r\n          Quality of NMN raw materials\r\n          <img decoding=\"async\" alt=\"btn\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/headline_circle_btn.png\"\/>\r\n<\/a>\r\n<\/p>\r\n<\/div>\r\n<div class=\"ivf pb10\">\r\n<p class=\"headline\">\r\n<a href=\"#treatise\">\r\n          References\r\n          <img decoding=\"async\" alt=\"btn\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/headline_circle_btn.png\"\/>\r\n<\/a>\r\n<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div id=\"activation\">\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n     What is sirtuin (longevity) gene activation by NMN drip therapy?\r\n    <\/h2>\r\n<div class=\"section-dept__content02_text\">\r\n<p>\r\n      It is everyone's wish to stay young and healthy forever.\r\n      <br\/>\r\n      However, as we age, our skin and physical strength decline, becoming more appropriate for our age.\r\n      <br\/>\r\n      So what causes aging? There are genes that are deeply involved in human aging and longevity.\r\n      <br\/>\r\n      That is the \"sirtuin gene (longevity gene).\"\r\n      <br\/>\r\n      Activation of this gene improves physical functions such as skin cells, physical strength, and fatigue, resulting in rejuvenation.\r\n      <br\/>\r\n      NMN infusion activates this sirtuin gene, helping you stay young forever and live a healthy life.\r\n     <\/p>\r\n<\/div>\r\n<div id=\"about_nmn\">\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n     What is NMN?\r\n    <\/h2>\r\n<div class=\"section-dept__content02_text\">\r\n                            <p>The official name is \"nicotinamide mononucleotide.\"<br>\r\n                                NMN is a vitamin-like substance that is made naturally in the body.<br>\r\n                                However, as we age, the amount produced in our bodies decreases.<br>\r\n                                It is thought that aging begins when NMN decreases in the body, and physical and cognitive functions deteriorate.<br>\r\n                                Study after study has found that ingesting this NMN dramatically changes the appearance and function of the body like turning back the hands of a clock, and it has attracted worldwide attention as a \"rejuvenation drug.\r\n                            <\/p>\r\n                            <p>Incidentally, foods that contain a lot of NMN include edamame, broccoli, and cucumber, but in the case of broccoli, if you want to ingest 100 mg of NMN per day, you will need about 40 kg (about 2000 bunches).<br>\r\n                                NMN can be efficiently taken into the body through intravenous drip.<!--Professor David Sinclair of Harvard Medical School says the following about NMN:--><\/p>\r\n                            <!--<div class=\"funin_flow mb20\">\r\n                                <p class=\"align_center bold pt10\">NMN was administered to 22-month-old mice, which is equivalent to 60 years old in humans.<br>\r\n                                    One week later, the mice had muscles equivalent to those of a 6-month-old mouse.<br>\r\n                                    This is equivalent to 20 years old in human terms.<br>\r\n                                    In other words, he became 40 years younger in just one week.<\/p>\r\n                            <\/div>-->\r\n\r\n                            <p class=\"mb30 mt100\">NMN has been suggested to potentially improve ovarian function, egg quality, and sperm quality.<\/p>\r\n                            <p class=\"text-indent: -1em;\r\n                            padding-left: 1em;\">\r\n                              <strong>\uff11\uff09Cell Prolif. 2022 Jul 10;55(11):e13303. doi: 10.1111\/cpr.13303<br>\r\n                              Administration of nicotinamide mononucleotide improves oocyte quality of obese mice<\/strong><br>\r\n                              Luyao Wang 1 2, Yurong Chen 1 2, Jiarui Wei 1 2, Fucheng Guo 1 2, Leyi Li 1 2, Zhen Han 1 2, Zhengzhu Wang 1 2, Haibo Zhu 3, Xiaoling Zhang 1 2, Ziyi Li 1 2, Xiangpeng Dai 1 2<br>\r\n                            <\/p>\r\n                            <!--<p>\r\n                              <strong>\uff12\uff092020 Aug 4;32(5):107987. doi: 10.1016\/j.celrep.2020.107987.<\/strong><br>\r\n                              Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes\r\n                              Yilong Miao 1, Zhaokang Cui 1, Qian Gao 2, Rong Rui 2, Bo Xiong 3\r\n                              Affiliations Expand<br>\r\n                            <br>\r\n                              Anim Biosci<br>\r\n                            <\/p>-->\r\n                            <p>\r\n                              <strong>\uff12\uff09 2020 Feb 11;30(6):1670-1681.e7. doi: 10.1016\/j.celrep.2020.01.058.<br>\r\n                              NAD+ Repletion Rescues Female Fertility during Reproductive Aging<\/strong><br>\r\n                              Michael J Bertoldo 1, Dave R Listijono 1, Wing-Hong Jonathan Ho 1, Angelique H Riepsamen 2, Dale M Goss 3, Dulama Richani 2, Xing L Jin 4, Saabah Mahbub 5, Jared M Campbell 5, Abbas Habibalahi 5, Wei-Guo Nicholas Loh 2, Neil A Youngson 3, Jayanthi Maniam 3, Ashley S A Wong 3, Kaisa Selesniemi 6, Sonia Bustamante 7, Catherine Li 3, Yiqing Zhao 2, Maria B Marinova 2, Lynn-Jee Kim 3, Laurin Lau 2, Rachael M Wu 8, A Stefanie Mikolaizak 9, Toshiyuki Araki 10, David G Le Couteur 11, Nigel Turner 3, Margaret J Morris 3, Kirsty A Walters 2, Ewa Goldys 5, Christopher O'Neill 4, Robert B Gilchrist 2, David A Sinclair 12, Hayden A Homer 13, Lindsay E Wu 14\r\n                              \r\n                            <\/p><p>\r\n                                <strong>\uff13\uff09Biomedicines. 2022 Jun 29;10(7):1544. doi: 10.3390\/biomedicines10071544<br>\r\n                                Unique Deep Radiomic Signature Shows NMN Treatment Reverses Morphology of Oocytes from Aged Mice<\/strong><br>\r\n                                Abbas Habibalahi 1,*, Jared M Campbell 1, Michael J Bertoldo 2,3, Saabah B Mahbub 1, Dale M Goss 3, William L Ledger 2, Robert B Gilchrist 2, Lindsay E Wu 3, Ewa M Goldys 1\r\n                                <\/p>\r\n                            <p>\r\n                              <strong>\uff14\uff092024 May;37(5):852-861. doi: 10.5713\/ab.23.0379. Epub 2024 Apr 1.<br>\r\n                              \u03b2-Nicotinamide mononucleotide improves chilled ram sperm quality in vitro by reducing oxidative stress damage<\/strong><br>\r\n                              Zhendong Zhu 1, Haolong Zhao 1, Qitai Yang 1, Yajing Li 1, RuYuan Wang 1, Adedeji Olufemi Adetunji 2, Lingjiang Min 1\r\n                            <\/p>\r\n                            <p class=\"mb100\">\r\n                              <strong>\uff15\uff09Antioxidants (Basel). 2024 Apr 24;13(5):507. doi: 10.3390\/antiox13050507<br>\r\n                              Supplementing Boar Diet with Nicotinamide Mononucleotide Improves Sperm Quality Probably through the Activation of the SIRT3 Signaling Pathway<\/strong><br>\r\n                              Haize Zhang 1, Jiawen Chai 1, Chaoyue Cao 1, Xiaolin Wang 1, Weijun Pang 1<br><br>\r\n                              Cell Rep\r\n                            <\/p>\r\n\r\n\r\n                            <p>No negative aspects have yet been discovered for NMN.<br>\r\n                                On the contrary, it is known to protect against eye diseases, hearing loss, and the liver and heart.<br>\r\n                                It sounds like a panacea, but it's a fact that laboratories around the world have confirmed.<\/p>\r\n                            <p>The rejuvenating ingredient NMN is absorbed into the body and then delivered to every corner of the body where it is converted into a substance called NAD+.<br>\r\n                                NAD+ is present in the bodies of all living creatures and influences their youth and health, but it begins to decline in the late teens, and by the time we reach our 40s, it is reduced to half its peak level, causing us to lose our youthfulness.<br>\r\n                                Therefore, an effective way to increase NAD+ concentration in the body is to supplement its raw material, NMN.\r\n                            <\/p>\r\n                            <p class=\"align_center\"><img decoding=\"async\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/assets\/images\/infertility\/decrease_eg.png\" alt=\"Decrease in NAD+ levels in the body due to aging\"><\/p>\r\n                            <p>Cite from the Thesis <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0042357\" target=\"_blank\" rel=\"noopener\">\"Age-Associated Changes In Oxdative Stress and NAD Metabolism InHuman Tissue Figure4\"<\/a><\/p>\r\n                        <\/div>\r\n<div id=\"disease\">\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n     Diseases with potential therapeutic effects\r\n    <\/h2>\r\n<div class=\"section-dept__content02_text\">\r\n<ul class=\"list_type1\">\r\n<li>\r\n       Aging (Aging Care)\u2026Improves the increase in aging genes\r\n      <\/li>\r\n<li>\r\n       Neurological disorder\u2026It restores dysfunction characteristic of neurological diseases\r\n      <\/li>\r\n<li>\r\n       Diabetes mellitus\u2026Restores decreased NAD+ and improves abnormal blood glucose levels\r\n      <\/li>\r\n<li>\r\n       Improving sleep quality\u2026It is effective for deep and effective sleep\r\n      <\/li>\r\n<li>\r\n       Improving muscle strength\u2026Walking speed, grip strength, and other values improve predominantly.\r\n      <\/li>\r\n<li>\r\n       Eye function\u2026Proven effective against eye aging\r\n      <\/li>\r\n<li>\r\n       Alzheimer's disease\u2026Effectively reduces \u03b2-amyloid production, amyloid plaque burden, synapse loss, etc\r\n      <\/li>\r\n<li>\r\n       Intracerebral hemorrhage\u2026Affects the resolution of vascular insufficiency caused by aging and antioxidant activity\r\n      <\/li>\r\n<li>\r\n       Obesity and its complications\u2026Improves muscle and liver function by activating mitochondria\r\n      <\/li>\r\n<\/ul>\r\n<p class=\"align_center\">\r\n<img decoding=\"async\" alt=\"Sirtuins and aging-related diseases\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/infertility\/aging_diseases01.png\"\/>\r\n<\/p>\r\n<p class=\"align_center\">\r\n<img decoding=\"async\" alt=\"Sirtuins and aging-related diseases graph\" class=\"mt30\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/infertility\/aging_diseases02.png\"\/>\r\n<\/p>\r\n<p>\r\n      Cite from the Thesis\r\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28068222\/\" target=\"_blank\" rel=\"noopener\">\r\n       \"Long-term administration of nicotinamide mononucleatidemitigates age assosiated physioligical decline in mice Figure1\"\r\n      <\/a>\r\n<\/p>\r\n<\/div>\r\n<div id=\"treatment\">\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n     Method of treatment\r\n    <\/h2>\r\n<div class=\"section-dept__content02_text\">\r\n<p>\r\n      A preparation containing NMN is infused into either the left or right arm.\r\n      <br\/>\r\n      The process takes approximately 15-30 minutes.\r\n     <\/p>\r\n<p>\r\n      *Although some effects can be seen even after a single treatment, those who wish to maintain health, prevent aging (anti-aging), and relieve fatigue can maintain the effects by continuing treatment once every 1-4 weeks.\r\n     <\/p>\r\n<\/div>\r\n<div id=\"side_effects\">\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n     Contraindications and side effects of NMN drip therapy\r\n    <\/h2>\r\n<div class=\"section-dept__content02_text\">\r\n<p>\r\n      Angialgia\r\n     <\/p>\r\n<\/div>\r\n<div id=\"nmn_fees\">\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n     NMN drip therapy cost\r\n    <\/h2>\r\n<div class=\"section-dept__content02_text\">\r\n<p>\r\n1 session \u00a513,200 (Tax included \u00a514,520)<br>\r\n\u203b Separate consultation and injection technique fees will apply.<br>\r\n\u203b The cost for NMN drip therapy will remain \u00a513,200 (Tax included \u00a514,520) until February 28, 2025. Starting from March 1, 2025, the price will increase to \u00a518,000 (Tax included \u00a519,800).\r\n     <\/p>\r\n<\/div>\r\n<div id=\"quality\">\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n     Quality of NMN raw materials\r\n    <\/h2>\r\n<div class=\"section-dept__content02_text\">\r\n<p>\r\n      Our NMN infusion uses the only NMN raw material \"N-Pro Med\u2122 (manufactured by Nordeste Inc.)\", which has been confirmed safe in research and proven to increase NAD+ in the blood, and a strict quality maintenance system and manufacturing control are implemented in the production process.\r\n      <br\/>\r\n      The effects confirmed in a study by Professor Akinobu Goto (Hyogo University of Medicine, School of Medicine) and others are as follows.\r\n     <\/p>\r\n<h3 class=\"section-dept__content03_title\">\r\n      Thesis summary\uff1a Safety of 300 mg of NMN administered intravenously. Intravenous NMN administration is considered safe and beneficial\r\n     <\/h3>\r\n<h4 class=\"section-top__guide_title\">\r\n      Effectiveness\r\n     <\/h4>\r\n<ul class=\"list_type1\">\r\n<li>\r\n       Increases the longevity molecule NAD+ level in the blood by approximately 20% (see NAD+ level chart)\r\n      <\/li>\r\n<li>\r\n       Improve sleep quality\r\n      <\/li>\r\n<li>\r\n       Blood fat (TG level) decreased by approximately 75% (see TG level chart)\r\n      <\/li>\r\n<li>\r\n       Improving TG levels may lead to the prevention and treatment of fatty liver and diabetes-related diseases\r\n      <\/li>\r\n<\/ul>\r\n<p>\r\n      In particular, the effect of reducing blood fat by approximately 75% after infusion has not been confirmed in previous studies of oral NMN administration, and is thought to be an effect unique to NMN infusion.\r\n     <\/p>\r\n<p class=\"align_center\">\r\n<img decoding=\"async\" alt=\"TG level chart\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/infertility\/tg_level_grapph.png\"\/>\r\n<\/p>\r\n<p class=\"align_center\">\r\n<img decoding=\"async\" alt=\"NAD+ level chart\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/infertility\/nad_graph.png\"\/>\r\n<\/p>\r\n<p>\r\n      Reference thesis\uff1a\r\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36225528\/\" target=\"_blank\" rel=\"noopener\">\r\n       \"Kimura et al., 2022 | Cureus Nicotinamide Mononucleotide Is Safety Metabolized and Signiflacantly Reduces Blood Triglyceride Levels in Healthy Individuals\"\r\n      <\/a>\r\n<br\/>\r\n      *It refers to the fact that no equivalent effect of NMN infusion has been reported prior to the publication of this thesis.\r\n     <\/p>\r\n<\/div>\r\n<div id=\"treatise\">\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n     Reference thesis\r\n    <\/h2>\r\n<div class=\"section-dept__content02_text\">\r\n<ul class=\"list_type1\">\r\n<li>\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9628229\/#\" target=\"_blank\" rel=\"noopener\">\r\n        Cell Prolif.\r\n       <\/a>\r\n       2022 Nov; 55(11): e13303.\r\n       <br\/>\r\n       Published online 2022 Jul 10. doi:\r\n       <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpr.13303\" target=\"_blank\" rel=\"noopener\">\r\n        10.1111\/cpr.13303\r\n       <\/a>\r\n<br\/>\r\n       PMCID: PMC9628229\r\n       <br\/>\r\n       PMID:\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35811338\/\" target=\"_blank\" rel=\"noopener\">\r\n        35811338\r\n       <\/a>\r\n<br\/>\r\n       Administration of nicotinamide mononucleotide improves oocyte quality of obese mice\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Wang%20L%5BAuthor%5D\" target=\"_blank\" rel=\"noopener\">\r\n        Luyao Wang\r\n       <\/a>\r\n       , 1 , 2\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Chen%20Y%5BAuthor%5D\" target=\"_blank\" rel=\"noopener\">\r\n        Yurong Chen\r\n       <\/a>\r\n       , 1 , 2\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Wei%20J%5BAuthor%5D\" target=\"_blank\" rel=\"noopener\">\r\n        Jiarui Wei\r\n       <\/a>\r\n       , 1 , 2\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Guo%20F%5BAuthor%5D\" target=\"_blank\" rel=\"noopener\">\r\n        Fucheng Guo\r\n       <\/a>\r\n       , 1 , 2\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Li%20L%5BAuthor%5D\" target=\"_blank\" rel=\"noopener\">\r\n        Leyi Li\r\n       <\/a>\r\n       , 1 , 2\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Han%20Z%5BAuthor%5D\" target=\"_blank\" rel=\"noopener\">\r\n        Zhen Han\r\n       <\/a>\r\n       , 1 , 2\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Wang%20Z%5BAuthor%5D\" target=\"_blank\" rel=\"noopener\">\r\n        Zhengzhu Wang\r\n       <\/a>\r\n       , 1 , 2\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zhu%20H%5BAuthor%5D\" target=\"_blank\" rel=\"noopener\">\r\n        Haibo Zhu\r\n       <\/a>\r\n       , 3\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zhang%20X%5BAuthor%5D\" target=\"_blank\" rel=\"noopener\">\r\n        Xiaoling Zhang\r\n       <\/a>\r\n       , 1 , 2\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Li%20Z%5BAuthor%5D\" target=\"_blank\" rel=\"noopener\">\r\n        Ziyi Li\r\n       <\/a>\r\n       , 1 , 2 and\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Dai%20X%5BAuthor%5D\" target=\"_blank\" rel=\"noopener\">\r\n        Xiangpeng Dai\r\n       <\/a>\r\n       1 , 2\r\n       <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9628229\/#\" target=\"_blank\" rel=\"noopener\">\r\n        Author information Article notes Copyright and License information PMC Disclaimer\r\n       <\/a>\r\n<\/li>\r\n<li class=\"mt20\">\r\n       Cell Prolif.\u00a02023 Aug;56(8):e13419.\u00a0doi: 10.1111\/cpr.13419.\u00a0Epub 2023 Feb 9.\r\n       <br\/>\r\n<strong>\r\n        Nicotinamide mononucleotide restores oxidative stress-related apoptosis of oocyte exposed to benzyl butyl phthalate in mice\r\n       <\/strong>\r\n<br\/>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Jiang+Y&amp;cauthor_id=36756972\" target=\"_blank\" rel=\"noopener\">\r\n        Yi Jiang\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-1\" target=\"_blank\" rel=\"noopener\">\r\n        1\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-2\" target=\"_blank\" rel=\"noopener\">\r\n        2\r\n       <\/a>\r\n       ,\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Wang+D&amp;cauthor_id=36756972\">\r\n        Di Wang\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-1\" target=\"_blank\" rel=\"noopener\">\r\n        1\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-2\" target=\"_blank\" rel=\"noopener\">\r\n        2\r\n       <\/a>\r\n       ,\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zhang+C&amp;cauthor_id=36756972\" target=\"_blank\" rel=\"noopener\">\r\n        Cheng Zhang\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-1\">\r\n        1\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-2\">\r\n        2\r\n       <\/a>\r\n       ,\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Jiao+Y&amp;cauthor_id=36756972\">\r\n        Yangyang Jiao\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-1\" target=\"_blank\" rel=\"noopener\">\r\n        1\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-2\" target=\"_blank\" rel=\"noopener\">\r\n        2\r\n       <\/a>\r\n       ,\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Pu+Y&amp;cauthor_id=36756972\" target=\"_blank\" rel=\"noopener\">\r\n        Yanan Pu\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-1\">\r\n        1\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-2\" target=\"_blank\" rel=\"noopener\">\r\n        2\r\n       <\/a>\r\n       ,\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Cheng+R&amp;cauthor_id=36756972\">\r\n        Rong Cheng\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-1\">\r\n        1\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-2\">\r\n        2\r\n       <\/a>\r\n       ,\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Li+C&amp;cauthor_id=36756972\" target=\"_blank\" rel=\"noopener\">\r\n        Chunyu Li\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-1\" target=\"_blank\" rel=\"noopener\">\r\n        1\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-2\" target=\"_blank\" rel=\"noopener\">\r\n        2\r\n       <\/a>\r\n       ,\r\n       <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Chen+Y&amp;cauthor_id=36756972\" target=\"_blank\" rel=\"noopener\">\r\n        Yan Chen\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-1\" target=\"_blank\" rel=\"noopener\">\r\n        1\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-2\" target=\"_blank\" rel=\"noopener\">\r\n        2\r\n       <\/a>\r\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36756972\/#full-view-affiliation-3\" target=\"_blank\" rel=\"noopener\">\r\n        3\r\n       <\/a>\r\n<br\/>\r\n       Affiliations\u00a0expand\r\n       <ul>\r\n<li>\r\n         PMID:\u00a036756972\r\n        <\/li>\r\n<li>\r\n         PMCID:\u00a0PMC10392047\r\n        <\/li>\r\n<li>\r\n         DOI:\u00a010.1111\/cpr.13419\r\n        <\/li>\r\n<\/ul>\r\n<\/li>\r\n<\/ul>\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n     About Consultation and Inquiries\r\n    <\/h2>\r\n<div class=\"mb100\">\r\n<!-- #BeginLibraryItem \"\/Library\/english_hd.lbi\" -->\r\n<div class=\"text_frame3 align_center mt25 mb0\">\r\n<p class=\"frame3_title rem17\">\r\n       English Help Desk\r\n      <\/p>\r\n<p class=\"mb0 rem20\">\r\n       TEL:\r\n       <a class=\"tel\" href=\"tel:070-1820-0909\">\r\n        070-1820-0909\r\n       <\/a>\r\n<\/p>\r\n<p class=\"mb0 rem20\">\r\n       Email:\r\n       <a href=\"mailto:english_help@oakclinic-group.com\">\r\n        english_help@oakclinic-group.com\r\n       <\/a>\r\n<\/p>\r\n<p>\r\n       [Reception time]\r\n       <br\/>\r\n       Monday-Sunday\u200309\uff1a00-17\uff1a00\r\n       <br\/>\r\n<\/p>\r\n<div class=\"section-dept__guide_btn_area\">\r\n<ul>\r\n<li class=\"section-dept__guide_btn guide_btn_w\">\r\n<a href=\"https:\/\/www.oakclinic-group.com\/en\/info\/info01\/\" target=\"_blank\" rel=\"noopener\">\r\n<p>\r\n           About English-Language Services\r\n          <\/p>\r\n<\/a>\r\n<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<!-- #EndLibraryItem -->\r\n<\/div>\r\n<\/section>\r\n<\/div>\r\n<\/div>","protected":false},"excerpt":{"rendered":"NMN drip therapy \u03b2-Nicotinamide Mononucleotide Sumiyoshi Umeda Ginza Activation of sirtuin (longevity) genes, reviving youthfulness Body fat percentage decreases, muscle percentage increases Restores physical strength I can sleep soundly Estrogen rise Breathing easier during exercise Improves skin texture, firmness, and whitening Mitochondrial activation clear one's head Improves thinking and concentration Metabolism increases What is sirtuin [&hellip;]","protected":false},"author":2,"featured_media":0,"parent":1253,"menu_order":371,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_locale":"en_US","_original_post":"https:\/\/www.oakclinic-group.com\/wp\/nmn_drip\/","footnotes":""},"class_list":["post-1263","page","type-page","status-publish","hentry","en-US"],"_links":{"self":[{"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/pages\/1263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/comments?post=1263"}],"version-history":[{"count":15,"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/pages\/1263\/revisions"}],"predecessor-version":[{"id":5370,"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/pages\/1263\/revisions\/5370"}],"up":[{"embeddable":true,"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/pages\/1253"}],"wp:attachment":[{"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/media?parent=1263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}