{"id":1115,"date":"2024-10-08T19:46:31","date_gmt":"2024-10-08T10:46:31","guid":{"rendered":"https:\/\/www.oakclinic-group.com\/wp\/ss_hairan\/"},"modified":"2024-11-12T17:14:50","modified_gmt":"2024-11-12T08:14:50","slug":"ss_hairan","status":"publish","type":"page","link":"https:\/\/www.oakclinic-group.com\/en\/funin\/ss_hairan\/","title":{"rendered":"Ovulation Induction Method of IVF"},"content":{"rendered":"<div class=\"section-dept__container\">\r\n<div class=\"section-dept__first_content\">\r\n<section class=\"section-dept__content01\">\r\n<h1 class=\"section-dept__content01_title\">\r\n     Ovulation Induction Method of IVF\r\n    <\/h1>\r\n<div class=\"section-dept__content01_text\">\r\n<div class=\"section-dept__content02_text\">\r\n<h4 class=\"section-top__guide_title\">\r\n       Types of ovulation induction methods\r\n      <\/h4>\r\n<div class=\"section-dept__content02_text mb0 pb0\">\r\n<div class=\"trigger_cap\">\r\n<div class=\"stimulation\">\r\n<div class=\"stimulation02\">\r\n<p class=\"headline\">\r\n           Stimulation Method\r\n           <img decoding=\"async\" alt=\"circle\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/headline_circle_btn.png\"\/>\r\n<\/p>\r\n<p>\r\n           Daily administration of ovulation inducers\r\n          <\/p>\r\n<figure>\r\n<img decoding=\"async\" alt=\"Stimulation Method\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/stimulation-method_image.png\"\/>\r\n<\/figure>\r\n<\/div>\r\n<ul>\r\n<li>\r\n<a href=\"#agonist\">\r\n            Agonist Method\r\n           <\/a>\r\n<ol>\r\n<li>\r\n<a href=\"#short\">\r\n              Short Method\r\n             <\/a>\r\n<\/li>\r\n<li>\r\n<a href=\"#long\">\r\n              Long Method\r\n             <\/a>\r\n<\/li>\r\n<li>\r\n<a href=\"#ultralong\">\r\n              Ultra Long Method\r\n             <\/a>\r\n<\/li>\r\n<\/ol>\r\n<\/li>\r\n<li>\r\n<a href=\"#antagonist\">\r\n            Antagonist Method\r\n           <\/a>\r\n<\/li>\r\n<li>\r\n<a href=\"#hmgmpa\">\r\n            HMG-MPA Method\r\n           <\/a>\r\n<\/li>\r\n<\/ul>\r\n<\/div>\r\n<div class=\"stimulation\">\r\n<div class=\"stimulation02\">\r\n<p class=\"headline\">\r\n           Medium Stimulation Method\r\n           <img decoding=\"async\" alt=\"circle\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/headline_circle_btn.png\"\/>\r\n<\/p>\r\n<p>\r\n           Administer ovulation drug every other day\r\n          <\/p>\r\n<figure>\r\n<img decoding=\"async\" alt=\"Medium Stimulation Method\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/m_stimulation-method_image.png\"\/>\r\n<\/figure>\r\n<\/div>\r\n<ul>\r\n<li>\r\n<a href=\"#cyushigeki\">\r\n<span>\r\n             Medium Stimulation Method\r\n             <br\/>\r\n<span class=\"possible\">\r\n              \uff08Random start possible\uff09\r\n             <\/span>\r\n<\/span>\r\n<\/a>\r\n<\/li>\r\n<\/ul>\r\n<\/div>\r\n<div class=\"stimulation\">\r\n<div class=\"stimulation02\">\r\n<p class=\"headline\">\r\n           Low- Medium Stimulation Method\r\n           <img decoding=\"async\" alt=\"circle\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/headline_circle_btn.png\"\/>\r\n<\/p>\r\n<p>\r\n           Ovulation induction with less burden on the body\r\n          <\/p>\r\n<figure>\r\n<img decoding=\"async\" alt=\"Medium Stimulation Metho\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sm_stimulation-method_image.png\"\/>\r\n<\/figure>\r\n<\/div>\r\n<ul>\r\n<li>\r\n<a href=\"#natural\">\r\n            Complete Natural Method\r\n           <\/a>\r\n<\/li>\r\n<li>\r\n<a href=\"#clomifene\">\r\n            Clomifene\r\n           <\/a>\r\n<\/li>\r\n<li>\r\n<a href=\"#sexovid\">\r\n            Sexovid\u00ae\r\n           <\/a>\r\n<\/li>\r\n<li>\r\n<a href=\"#femara\">\r\n            Letrozole\r\n           <\/a>\r\n<\/li>\r\n<li>\r\n<a href=\"#estrogen\">\r\n            HRT-OPU Method\r\n           <\/a>\r\n<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<div class=\"section-dept__guide_btn_area mt0 mb30\">\r\n<ul class=\"mb20\">\r\n<li class=\"section-dept__guide_btn guide_btn_w\">\r\n<a href=\"https:\/\/www.oakclinic-group.com\/en\/funin\/fees_simulation\/\">\r\n<p>\r\n            Cost Simulation\r\n           <\/p>\r\n<\/a>\r\n<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<div class=\"section-dept__content02_text\">\r\n<h4 class=\"section-top__guide_title\">\r\n        Considerations in Selecting an Ovulation Induction Method\r\n       <\/h4>\r\n<div class=\"list_type1 text_frame\">\r\n<ul>\r\n<li>\r\n          Pituitary Hormone (FSH LH)\r\n         <\/li>\r\n<li>\r\n          Ovarian Hormone (E\r\n          <span class=\"txt_shita rem12\">\r\n           2\r\n          <\/span>\r\n          P\r\n          <span class=\"txt_shita rem12\">\r\n           4\r\n          <\/span>\r\n          )\r\n         <\/li>\r\n<li>\r\n          AMH\r\n         <\/li>\r\n<li>\r\n          Age\r\n         <\/li>\r\n<li>\r\n          Male factor (semen observation, age)\r\n         <\/li>\r\n<li>\r\n          Previous Oocyte Pick-up Cycles\r\n         <\/li>\r\n<li>\r\n          Possible number of visits\r\n         <\/li>\r\n<li>\r\n          Whether or not there is a limit on the oocyte pick-up day\r\n         <\/li>\r\n<li>\r\n          Either one or both members of the couple live far away or overseas\r\n         <\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<h1 class=\"section-dept__content01_title\">\r\n       Features of Each Method\r\n      <\/h1>\r\n<div class=\"section-dept__content01_text\">\r\n<div class=\"section-dept__content02_text\">\r\n<p>\r\n         Continue reading to see advantages, considerations, purposes, and costs.\r\n        <\/p>\r\n<\/div>\r\n<\/div>\r\n<div id=\"stimulation\">\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n       Stimulation Method\r\n      <\/h2>\r\n<div class=\"section-dept__content02_text\">\r\n<p>\r\n        FSH\/HMG injection is administered from the third day of the menstrual cycle. The type and dose vary.\r\n       <\/p>\r\n<p>\r\n        Usually, the dose is 150 IU a day for people in their 20s, 150-300 IU for people in their 30s, 300 IU for people in their late 30s to 40s, and 450 IU for cases with poor response. (Recombinant products such as Gonal F \u00ae are used in a slightly smaller amount.)\r\n        <br\/>\r\n        The follicle size can be measured appropriately and the number of oocytes collected can be adjusted.\r\n       <\/p>\r\n<p>\r\n        Agonists (mainly nasal drops, rarely subcutaneous injections) and antagonists (abdominal subcutaneous injections) are used as methods to suppress ovulation before oocyte pick-up.\r\n        <br\/>\r\n        Recently, a new method using MPA (internal use) has been adopted.\r\n       <\/p>\r\n<p>\r\n        There is a short method, a long method, and an ultra-long method depending on the time when the agonist is started.\r\n        <br\/>\r\n        The short method starts from the first day of menstruation, the long method starts from the high temperature metaphase of the previous cycle, and the ultra-long method starts from several months prior.\r\n       <\/p>\r\n<p>\r\n        The antagonist is usually given as 3mg on the 6th day of the menstrual cycle, and then added every 4 days until the oocyte pick-up schedule is prepared.\r\n       <\/p>\r\n<p class=\"mb0\">\r\n        The HMG-MPA method is used in combination with 10mg daily when ovulation is induced.\r\n       <\/p>\r\n<\/div>\r\n<div class=\"section-dept__content02_text\">\r\n<div class=\"fee_box\">\r\n<table>\r\n<tbody>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Advantage\r\n           <\/td>\r\n<td>\r\n            \u30fbThe number of oocytes collected is large, and good oocytes can be selected.\r\n            <br\/>\r\n            \u30fbEasy to secure frozen oocytes.\r\n            <br\/>\r\n            \u30fbThe endometrium does not become thin.\r\n            <br\/>\r\n            \u30fbThe number of developing follicles can be controlled.\r\n            <br\/>\r\n            \u30fbThere are few post-ovulation troubles and fewer vacuoles (especially when an agonist is used).\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Points to Consider\r\n           <\/td>\r\n<td>\r\n            \u30fbIt is necessary to go to the hospital for injections every day (however, self-injection and injection at a nearby doctor are also possible)\r\n            <br\/>\r\n            \u30fbMay develop ovarian hyperstimulation syndrome (OHSS)\r\n            <br\/>\r\n            \u30fbIf the number of developing follicles is large (10 in our hospital), all embryos will be frozen to avoid ovarian stimulation syndrome, so embryo transfer may not be possible in the same cycle.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Good Candidates\r\n           <\/td>\r\n<td>\r\n            \u30fbThose who have a large number of desired oocytes\r\n            <br\/>\r\n            \u30fbThose who want to freeze many embryos.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Cost Notes\r\n           <\/td>\r\n<td>\r\n            Since the amount of injections increases and the number of frozen oocytes increases, the cost for collecting oocytes at one time is high, but if multiple frozen oocytes can be secured, the number of oocyte pick-ups will decrease accordingly, so on the contrary, in total It can be kept low.\r\n           <\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<p>\r\n        The advantages and disadvantages of each stimulation method are described below.\r\n       <\/p>\r\n<\/div>\r\n<div id=\"agonist\">\r\n<\/div>\r\n<h3 class=\"section-dept__content03_title mb20\">\r\n       Agonist Method\r\n      <\/h3>\r\n<div class=\"section-dept__content02_text\" id=\"short\">\r\n<h3 class=\"text_frame color_yellow bold\">\r\n        Short Method\r\n       <\/h3>\r\n<div class=\"fee_box\">\r\n<table>\r\n<tbody>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Advantages\r\n           <\/td>\r\n<td>\r\n            \u30fbFor 2-3 days immediately after the start of the agonist, flare-up of pituitary hormone (rebounding after suppression) can be used for follicle development.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Points to Consider\r\n           <\/td>\r\n<td>\r\n            \u30fbAgonists cannot be used for oocyte maturation, and HCG is used, which may lead to ovarian hyperstimulation syndrome.\r\n            <br\/>\r\n            \u30fbIf the ovarian reserve is low, the suppression may be too effective and follicle development deteriorates.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Good Candidate\r\n           <\/td>\r\n<td>\r\n            The majority of people who have good ovarian reserve.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Remarks\r\n           <\/td>\r\n<td>\r\n            There is also an ultra-short method in which the agonist is used for only 2 to 3 days and only flare-up is used, but in that case, it is necessary to use an antagonist to suppress ovulation.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td colspan=\"2\">\r\n            Schedule example (Average schedule. The actual schedule is decided on an individual basis.)\r\n            <p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"schedule\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-short01.gif\" width=\"641\"\/>\r\n<\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"explanation\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-mark03.gif\" width=\"632\"\/>\r\n<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<div id=\"long\">\r\n<\/div>\r\n<h3 class=\"text_frame color_yellow bold mt0\">\r\n        Long method\r\n       <\/h3>\r\n<div class=\"fee_box\">\r\n<table>\r\n<tbody>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Advantages\r\n           <\/td>\r\n<td>\r\n            \u30fbSince the pituitary hormone is completely suppressed before the fertility drug is started, follicle development becomes uniform.\r\n            <br\/>\r\n            \u30fbThere is almost no possibility of ovulation.\r\n            <br\/>\r\n            \u30fbTherefore, it is easy to control oocyte pick-up date.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Points to Consider\r\n           <\/td>\r\n<td>\r\n            \u30fbSince the pituitary hormone is completely suppressed, the injection amount is increased.\r\n            <br\/>\r\n            \u30fbIf the ovarian reserve is low, follicles will not grow.\r\n            <br\/>\r\n            \u30fbContraception in the previous cycle is required.\r\n            <br\/>\r\n            \u30fbAgonists cannot be used for oocyte maturation, and HCG is used, which may lead to ovarian hyperstimulation syndrome.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Good Candidate\r\n           <\/td>\r\n<td>\r\n            \u30fbPolycystic ovary (PCO)\r\n            <br\/>\r\n            \u30fbYounger people\r\n            <br\/>\r\n            \u30fbThose who need to control the oocyte pick-up date\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td colspan=\"2\">\r\n<p>\r\n             Schedule example (Average schedule. The actual schedule is decided on an individual basis.)\r\n            <\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"schedule\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche_long.gif\" width=\"641\"\/>\r\n<\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"explanation\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-mark03.gif\" width=\"632\"\/>\r\n<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<div id=\"ultralong\">\r\n<\/div>\r\n<h3 class=\"text_frame color_yellow bold mt0\">\r\n        Ultra-Long Method\r\n       <\/h3>\r\n<p class=\"float_left mr10\" style=\"width: 198px\">\r\n<img loading=\"lazy\" decoding=\"async\" alt=\"Ultra-Long Method\" height=\"125\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/img-ultralong.jpg\" width=\"198\"\/>\r\n<\/p>\r\n<p class=\"mb0\">\r\n        Ovulation induction begins after pituitary hormone is completely suppressed for several months.\r\n        <br\/>\r\n        At the time of beginning injections, there is no menstruation.\r\n        <br\/>\r\n        Subcutaneous injections such as Leuprorelin\u00ae, nasal drops Buserelin\u00ae, and Sprecure\u00ae are used to suppress the pituitary gland.\r\n        <br\/>\r\n        The rest is the same as the long method. For people with endometriosis, especially adenomyosis, it is often done to improve the implantation environment.\r\n       <\/p>\r\n<\/div>\r\n<div class=\"section-dept__content02_text\">\r\n<div class=\"fee_box\">\r\n<table>\r\n<tbody>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Advantages\r\n           <\/td>\r\n<td>\r\n            \u30fbImplantation environment for people with endometriosis improves\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Points to Consider\r\n           <\/td>\r\n<td>\r\n            \u30fbFollicles do not grow when ovarian reserve is low\r\n            <br\/>\r\n            \u30fbPituitary suppression continues for a while\r\n            <br\/>\r\n            \u30fbThe amount of injection increases because the pituitary hormone is completely suppressed\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Good Candidate\r\n           <\/td>\r\n<td>\r\n            \u30fbThose with endometriosis\r\n            <br\/>\r\n            \u30fbThose with uterine fibroids\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td colspan=\"2\">\r\n<p>\r\n             Schedule example (Average schedule. The actual schedule is decided on an individual basis.)\r\n            <\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"schedule\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche_ulong02.gif\" width=\"641\"\/>\r\n<\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"explanation\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-mark03.gif\" width=\"632\"\/>\r\n<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<\/div>\r\n<div id=\"antagonist\">\r\n<\/div>\r\n<h3 class=\"section-dept__content03_title mb20\">\r\n       Antagonist Method\r\n      <\/h3>\r\n<div class=\"section-dept__content02_text\" id=\"hmgcetro\">\r\n<h3 class=\"text_frame color_yellow bold\">\r\n        HMG Cetro Method\r\n       <\/h3>\r\n<p class=\"float_left mr10\" style=\"width: 116px\">\r\n<img loading=\"lazy\" decoding=\"async\" alt=\"HMG Cetro Method\" height=\"100\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/img-hmgcetro01.jpg\" width=\"116\"\/>\r\n<\/p>\r\n<p class=\"mb0\">\r\n        HMG injections begin on the 3rd day of the menstrual cycle.\r\n        <br\/>\r\n        From the 6th day of the menstrual cycle, Cetrotide\u00ae 3 mg is subcutaneously injected into the abdomen.\r\n        <br\/>\r\n        Medication is aded every 4 days until the follicle is fully developed and oocyte pick-up is decided.\r\n       <\/p>\r\n<div class=\"fee_box\">\r\n<table>\r\n<tbody>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Advantages\r\n           <\/td>\r\n<td>\r\n            \u30fbSince the pituitary hormone is not suppressed from the initial stage, follicles are more likely to grow than the agonist method.\r\n            <br\/>\r\n            \u30fbUnlike agonists, pituitary suppression does not take a long time and is temporary.\r\n            <br\/>\r\n            \u30fbThe risks related to OHSS are reduced because oocyte maturation can be performed with agonist nasal drops without using HCG.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Points to Consider\r\n           <\/td>\r\n<td>\r\n            \u30fbDue to the high cost of antagonist medication, the cost is high if follicle development is slow.\r\n            <br\/>\r\n            \u30fbCompared to agonists, there is a slight possibility of premature ovulation.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Good Candidate\r\n           <\/td>\r\n<td>\r\n            \u30fbThose who have 3 or less developing follicles when using the short method.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td colspan=\"2\">\r\n<p>\r\n             Schedule example (Average schedule. The actual schedule is decided on an individual basis.)\r\n            <\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"schedule\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche_hmg.gif\" width=\"641\"\/>\r\n<\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"explanation\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-mark03.gif\" width=\"632\"\/>\r\n<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<\/div>\r\n<div id=\"hmgmpa\">\r\n<\/div>\r\n<h3 class=\"section-dept__content03_title mb10\">\r\n       HMG-MPA Method\r\n      <\/h3>\r\n<div class=\"section-dept__content02_text\">\r\n<p>\r\n        HMG injection and oral medication are used, starting from the 3rd day of the menstrual cycle.\r\n       <\/p>\r\n<div class=\"fee_box\">\r\n<table>\r\n<tbody>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Advantages\r\n           <\/td>\r\n<td>\r\n<p>\r\n             \u30fbSince the internal medicine is very cheap, the cost can be reduced.\r\n             <br\/>\r\n             \u30fbIf self-injection is used, there are few restrictions on the dates of visit.\r\n             <br\/>\r\n             \u30fbSince the pituitary hormone is not suppressed from the initial stage, follicles are more likely to grow than the agonist method.\r\n             <br\/>\r\n             \u30fbUnlike agonists, pituitary suppression does not take a long time and is temporary.\r\n             <br\/>\r\n             \u30fbThe risks related to OHSS are reduced because oocyte maturation can be performed with agonist nasal drops without using HCG.\r\n             <br\/>\r\n             \u30fbA \"random start method\" can be used to induce ovulation regardless of the menstrual cycle is possible.\r\n            <\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Points to Consider\r\n           <\/td>\r\n<td>\r\n<p>\r\n             \u30fbFresh embryo transfer is not possible.\r\n             <br\/>\r\n             \u30fbCompared to agonists, there is a slight possibility of premature ovulation.\r\n            <\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Good Candidate\r\n           <\/td>\r\n<td>\r\n<p>\r\n             \u30fbThose who want to reduce the number of visits.\r\n             <br\/>\r\n             \u30fbIn the case of the random start method, those who are far away, those who need urgent ovulation induction such as before breast cancer treatment.\r\n            <\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td colspan=\"2\">\r\n<p>\r\n             Schedule example (Average schedule. The actual schedule is decided on an individual basis.)\r\n            <\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"schedule\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche_mpa.gif\" width=\"641\"\/>\r\n<\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"explanation\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-mark03.gif\" width=\"632\"\/>\r\n<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n       Medium Stimulation Method\r\n      <\/h2>\r\n<div class=\"section-dept__content02_text\" id=\"cyushigeki\">\r\n<h3 class=\"section-dept__content03_title\">\r\n        Medium Stimulation Method\r\n       <\/h3>\r\n<p>\r\n        From the 3rd day of the menstrual cycle, oral medication and HMG injection proceeds every other day.\r\n       <\/p>\r\n<div class=\"fee_box\">\r\n<table>\r\n<tbody>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Advantages\r\n           <\/td>\r\n<td>\r\n<p>\r\n             \u30fbIf self-injection is used, there are few restrictions on the date of visit.\r\n             <br\/>\r\n             \u30fbIf there is a risk of OHSS, it is safe because oocyte maturation can be performed with agonist nasal drops without using HCG.\r\n             <br\/>\r\n             \u30fbA \"random start method\" can be used regardless of the menstrual cycle\r\n            <\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Points to Consider\r\n           <\/td>\r\n<td>\r\n<p>\r\n             \u30fbFresh embryo transfer is not possible.\r\n            <\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Good Candidate\r\n           <\/td>\r\n<td>\r\n<p>\r\n             \u30fbThose who want to reduce the number of visits.\r\n             <br\/>\r\n             \u30fbIn the case of the random start method, those who are far away.\r\n             <br\/>\r\n             \u30fbThose who do not mind that letrozole is not applicable and its use as an ovulation inducer has not yet been generally approved.\r\n            <\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td colspan=\"2\">\r\n<p>\r\n             Schedule example (Average schedule. The actual schedule is decided on an individual basis.)\r\n            <\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"schedule\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-cyu.jpg\" width=\"641\"\/>\r\n<\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"explanation\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-mark03.gif\" width=\"632\"\/>\r\n<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n       Low\/Medium Stimulation Method\r\n      <\/h2>\r\n<div class=\"section-dept__content02_text\" id=\"natural\">\r\n<h3 class=\"section-dept__content03_title\">\r\n        Natural Method\r\n       <\/h3>\r\n<p>\r\n        As a general rule, medicine is not used, whether oral or injection.\r\n        <br\/>\r\n        However, antagonists and HMGs may be used once or twice to prevent ovulation before oocyte pick-up.\r\n       <\/p>\r\n<div class=\"fee_box\">\r\n<table class=\"mb40\">\r\n<tbody>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Advantages\r\n           <\/td>\r\n<td>\r\n            \u30fbHospital visits are few.\r\n            <br\/>\r\n            \u30fbBecause no ovulation inducer is used, the burden on the body is little.\r\n            <br\/>\r\n            \u30fbContinuous cycle oocyte pick-up is possible.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Points to Consider\r\n           <\/td>\r\n<td>\r\n            \u30fbImpossible if the menstrual cycle is irregular.\r\n            <br\/>\r\n            \u30fbSince oocytes are collected each time, the number of oocyte pick-ups increases.\r\n            <br\/>\r\n            \u30fbSometimes it is an empty follicle.\r\n            <br\/>\r\n            \u30fbIf ovulation occurs prematurely, it may not be possible to collect oocytes.\r\n            <br\/>\r\n            \u30fbSince only one oocyte can be collected, there are cases where embryo transfer or freezing is not possible due to poor fertilization or division.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Good Candidate\r\n           <\/td>\r\n<td>\r\n            \u30fbThose who are 44 years old or older, have low ovarian reserve such as low AMH, or who request this.\r\n            <br\/>\r\n            \u30fbWhen FSH is high.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Cost\r\n           <\/td>\r\n<td>\r\n            The cost for each cycle of oocyte pick-up is the lowest because the number of oocytes collected is one and freezing costs are often unnecessary.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td colspan=\"2\">\r\n<p>\r\n             Schedule example (Average schedule. The actual schedule is decided on an individual basis.)\r\n            <\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"schedule\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-natu01.gif\" width=\"641\"\/>\r\n<\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"explanation\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-mark03.gif\" width=\"632\"\/>\r\n<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<div id=\"clomifene\">\r\n<\/div>\r\n<h3 class=\"section-dept__content03_title\">\r\n        Clomiphene (Clomid\u00ae or Cellophene\u00ae) method\r\n       <\/h3>\r\n<p class=\"float_left mr10\" style=\"width: 150px\">\r\n<img loading=\"lazy\" decoding=\"async\" alt=\"Clomiphene\" height=\"38\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/img-clomifene.jpg\" width=\"150\"\/>\r\n<\/p>\r\n<p>\r\n        Start taking medicine from the 3rd day of the menstrual cycle. The number of developing follicles may be adjusted in combination with HMG injection and Cetrotide.\r\n       <\/p>\r\n<div class=\"fee_box\">\r\n<table class=\"mb40\">\r\n<tbody>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Advantages\r\n           <\/td>\r\n<td>\r\n            \u30fbSince it is an oral drug, the number of hospital visits is small.\r\n            <br\/>\r\n            \u30fbContinuous oocyte pick-up is possible.\r\n            <br\/>\r\n            \u30fbFirst choice of PCO patients.\r\n            <br\/>\r\n            \u30fbThe cost per cycle is low because the number of oocytes collected is small and the number of frozen oocytes is small.\r\n            <br\/>\r\n            \u30fbHowever, if it is unsuccessful, it will be carried out from oocyte pick-up, so the cost per 2 to 3 cycles will be slightly higher.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Points to Consider\r\n           <\/td>\r\n<td>\r\n            Since the endometrium becomes thin, fresh embryo transfer may be impossible.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Good Candidate\r\n           <\/td>\r\n<td>\r\n            \u30fbThose who want the most natural method, but would like to collect 2 or 3 ovum if possible\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td colspan=\"2\">\r\n<p>\r\n             Schedule example (Average schedule. The actual schedule is decided on an individual basis.)\r\n            <\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"schedule\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche_clom.gif\" width=\"641\"\/>\r\n<\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"explanation\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-mark03.gif\" width=\"632\"\/>\r\n<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<div id=\"sexovid\">\r\n<\/div>\r\n<h3 class=\"section-dept__content03_title\">\r\n        Sexovid\u00ae Method\r\n       <\/h3>\r\n<p class=\"float_left mr20\" style=\"width: 71px;\">\r\n<img loading=\"lazy\" decoding=\"async\" alt=\"Sexovid\" height=\"51\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/img-sexovid.jpg\" width=\"71\"\/>\r\n<\/p>\r\n<p>\r\n        This uses a medication called Cyclophenyl. It is a non-steroidal fertility drug with a weak estrogenic effect.\r\n        <br\/>\r\n        It is said to act on the pituitary gland and promote gonadotropin secretion, but there are still many unclear points.\r\n        <br\/>\r\n        It has a weaker ovulation-inducing effect than clomiphene.\r\n        <br\/>\r\n        Injections may be used as well during the cycle.\r\n        <br\/>\r\n        Medication is taken for 5 days, starting from the 3rd day of the menstrual cycle.\r\n       <\/p>\r\n<div class=\"fee_box\">\r\n<table class=\"mb40\">\r\n<tbody>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Advantages\r\n           <\/td>\r\n<td>\r\n            \u30fbSince it is an oral drug, the number of hospital visits is small.\r\n            <br\/>\r\n            \u30fbContinuous oocyte pick-up is possible\r\n            <br\/>\r\n            \u30fbCompared to clomiphene, the endometrium does not become thinner, so embryo transfer in the same cycle is often possible.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Points to Consider\r\n           <\/td>\r\n<td>\r\n            \u30fbOvulation induction is weak, and the number of developing follicles is 1 in most cases.\r\n            <br\/>\r\n            Oocytes cannot be frozen this way.\r\n            <br\/>\r\n            \u30fbCompared to clomiphene, LH surge is more likely to occur when the follicle is small, and the risk of ovulation before oocyte pick-up is high.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Cost\r\n           <\/td>\r\n<td>\r\n            Similar to natural cycle.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td colspan=\"2\">\r\n<p>\r\n             Schedule example (Average schedule. The actual schedule is decided on an individual basis.)\r\n            <\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"schedule\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche_clom.gif\" width=\"641\"\/>\r\n<\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"explanation\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-mark03.gif\" width=\"632\"\/>\r\n<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<div id=\"femara\">\r\n<\/div>\r\n<h3 class=\"section-dept__content03_title\">\r\n        Letrozole (or anastrozole\u00ae) method\r\n       <\/h3>\r\n<p class=\"float_left mr10\" style=\"width: 134px\">\r\n<img loading=\"lazy\" decoding=\"async\" alt=\"Letrozole\" height=\"48\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/img-letro.jpg\" width=\"134\"\/>\r\n<\/p>\r\n<p>\r\n        Originally used as a treatment for postmenopausal breast cancer.\r\n        <br\/>\r\n        It is said that it inhibits aromatase, which is an enzyme required to convert male hormones to estradiol in the ovary, so it suppresses estradiol generation and increases FSH secretion with negative feedback to induce ovulation, but there are still unclear points.\r\n        <br\/>\r\n        Used in the same way as clomiphene from the 3rd day of the menstrual cycle.\r\n       <\/p>\r\n<div class=\"fee_box\">\r\n<table class=\"mb40\">\r\n<tbody>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Advantages\r\n           <\/td>\r\n<td>\r\n            \u30fbIt has little anti-estrogen effect and the endometrium does not become thin.\r\n            <br\/>\r\n            \u30fbFollicles may develop even in cases of decreased ovarian reserve where clomiphene does not work.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Points to Consider\r\n           <\/td>\r\n<td>\r\n            \u30fbIts use as an ovulation inducer has not yet been generally approved.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Good Candidate\r\n           <\/td>\r\n<td>\r\n            \u30fbExamples of stunted follicle growth with clomiphene.\r\n            <br\/>\r\n            \u30fbHistory of breast cancer.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td colspan=\"2\">\r\n<p>\r\n             Schedule example (Average schedule. The actual schedule is decided on an individual basis.)\r\n            <\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"schedule\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche_clom.gif\" width=\"641\"\/>\r\n<\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"explanation\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-mark03.gif\" width=\"632\"\/>\r\n<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<div id=\"estrogen\">\r\n<\/div>\r\n<h3 class=\"section-dept__content03_title\">\r\n        HRT-OPU Method\r\n       <\/h3>\r\n<p>\r\n        Uses estrogen to cause follicle development by the rebound effect.\r\n       <\/p>\r\n<div class=\"fee_box\">\r\n<table class=\"mb40\">\r\n<tbody>\r\n<tr>\r\n<td class=\"color_gray align_center\" style=\"width: 25%;\">\r\n            Good Candidate\r\n           <\/td>\r\n<td width=\"538\">\r\n            \u30fbThose who have difficulty in developing follicles.\r\n           <\/td>\r\n<\/tr>\r\n<tr>\r\n<td colspan=\"2\">\r\n<p>\r\n             Schedule example (Average schedule. The actual schedule is decided on an individual basis.)\r\n            <\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"schedule\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche_estro.gif\" width=\"641\"\/>\r\n<\/p>\r\n<p class=\"align_center mt20 mb20\">\r\n<img decoding=\"async\" alt=\"explanation\" height=\"auto\" src=\"https:\/\/www.oakclinic-group.com\/wp\/wp-content\/themes\/oak-clinic\/en\/assets\/images\/funin\/sche-mark03.gif\" width=\"632\"\/>\r\n<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<\/div>\r\n<div id=\"expense\">\r\n<\/div>\r\n<h2 class=\"section-dept__content02_title\">\r\n       Cost Simulation\r\n      <\/h2>\r\n<div class=\"section-dept__content02_text\">\r\n<div class=\"section-dept__guide_btn_area mt0 mb30\">\r\n<ul class=\"mb20\">\r\n<li class=\"section-dept__guide_btn guide_btn_w\">\r\n<a href=\"https:\/\/www.oakclinic-group.com\/en\/funin\/fees_simulation\/\">\r\n<p>\r\n            Cost Simulation\r\n           <\/p>\r\n<\/a>\r\n<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/section>\r\n<\/div>\r\n<\/div>","protected":false},"excerpt":{"rendered":"Ovulation Induction Method of IVF Types of ovulation induction methods Stimulation Method Daily administration of ovulation inducers Agonist Method Short Method Long Method Ultra Long Method Antagonist Method HMG-MPA Method Medium Stimulation Method Administer ovulation drug every other day Medium Stimulation Method \uff08Random start possible\uff09 Low- Medium Stimulation Method Ovulation induction with less burden on [&hellip;]","protected":false},"author":2,"featured_media":0,"parent":1118,"menu_order":235,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_locale":"en_US","_original_post":"https:\/\/www.oakclinic-group.com\/wp\/?page_id=731","footnotes":""},"class_list":["post-1115","page","type-page","status-publish","hentry","en-US"],"_links":{"self":[{"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/pages\/1115","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/comments?post=1115"}],"version-history":[{"count":4,"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/pages\/1115\/revisions"}],"predecessor-version":[{"id":4285,"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/pages\/1115\/revisions\/4285"}],"up":[{"embeddable":true,"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/pages\/1118"}],"wp:attachment":[{"href":"https:\/\/www.oakclinic-group.com\/wp-json\/wp\/v2\/media?parent=1115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}