{"id":8254,"date":"2024-08-02T17:04:28","date_gmt":"2024-08-02T08:04:28","guid":{"rendered":"https:\/\/www.oakclinic-group.com\/blog\/?p=8254"},"modified":"2024-08-02T17:04:31","modified_gmt":"2024-08-02T08:04:31","slug":"maple-syrup-urine-disease","status":"publish","type":"post","link":"https:\/\/www.oakclinic-group.com\/blog\/2024\/08\/02\/maple-syrup-urine-disease\/","title":{"rendered":"\u30e1\u30fc\u30d7\u30eb\u30b7\u30ed\u30c3\u30d7\u5c3f\u75c7"},"content":{"rendered":"\n

\u300cGenome First\uff08\u30b2\u30ce\u30e0\u30fb\u30d5\u30a1\u30fc\u30b9\u30c8\uff09\u300d\u3068\u3044\u3046\u8a00\u8449\u3092\u3054\u5b58\u3058\u3067\u3057\u3087\u3046\u304b\u3002\u500b\u3005\u306e\u60a3\u8005\u69d8\u306e\u30b2\u30ce\u30e0\u60c5\u5831\u3092\u533b\u7642\u3084\u5065\u5eb7\u7ba1\u7406\u306e\u6700\u524d\u7dda\u306b\u7f6e\u304f\u3053\u3068\u3092\u76ee\u6307\u3059\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u6307\u3057\u307e\u3059\u3002<\/p>\n\n\n

\n
\"\"<\/figure><\/div>\n\n\n

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<\/div>\n\n\n\n
    \n
  • \u65b0\u751f\u5150\u671f\u306e\u55dc\u7720<\/li>\n\n\n\n
  • \u6388\u4e73\u56f0\u96e3<\/li>\n\n\n\n
  • \u5614\u5410<\/li>\n\n\n\n
  • \u7b4b\u7dca\u5f35\u4f4e\u4e0b\uff08\u4f4e\u5f35\u6027\uff09<\/li>\n\n\n\n
  • \u7570\u5e38\u306a\u52d5\u304d\uff08\u821e\u8e0f\u75c5\u69d8\u904b\u52d5\uff09<\/li>\n\n\n\n
  • \u4ee3\u8b1d\u6027\u30a2\u30b7\u30c9\u30fc\u30b7\u30b9<\/li>\n\n\n\n
  • \u9ad8\u30a2\u30f3\u30e2\u30cb\u30a2\u8840\u75c7<\/li>\n\n\n\n
  • \u660f\u7761<\/li>\n<\/ul>\n\n\n\n
    <\/div>\n\n\n\n

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    \u591a\u304f\u306e\u56fd\u3067\u306f\u3001MSUD\u3092\u542b\u3080\u4ee3\u8b1d\u7570\u5e38\u3092\u65e9\u671f\u767a\u898b\u3059\u308b\u305f\u3081\u306b\u65b0\u751f\u5150\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304c\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8840\u6db2\u3092\u5206\u6790\u3057\u3001\u7279\u5b9a\u306e\u30a2\u30df\u30ce\u9178\u3084\u305d\u306e\u4ee3\u8b1d\u7523\u7269\u306e\u7570\u5e38\u5024\u3092\u691c\u51fa\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u75c7\u72b6\u306e\u30d1\u30bf\u30fc\u30f3\u306b\u3088\u308a\u3001\u5168\u3066\u304c\u691c\u51fa\u3055\u308c\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002 \u81e8\u5e8a\u75c7\u72b6\u304c\u7591\u308f\u3057\u3044\u5834\u5408\u3084\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb\u5f8c\u306e\u78ba\u5b9a\u8a3a\u65ad\u306b\u306f\u751f\u5316\u5b66\u7684\u691c\u67fb\u304c\u7528\u3044\u3089\u308c\u307e\u3059\u3002\u8840\u6db2\u3084\u5c3f\u4e2d\u306eBCAA\u3084\u305d\u306e\u4ee3\u8b1d\u7523\u7269\uff08\u7279\u306b\u30ed\u30a4\u30b7\u30f3\u3001\u30a4\u30bd\u30ed\u30a4\u30b7\u30f3\u3001\u30d0\u30ea\u30f3\u3001\u305d\u3057\u3066\u5206\u679d\u9396\u03b1-\u30b1\u30c8\u9178\uff09\u306e\u6fc3\u5ea6\u3092\u6e2c\u5b9a\u3057\u307e\u3059\u3002\u7279\u306b\u3001\u5c3f\u4e2d\u306e\u7570\u5e38\u306a\u6709\u6a5f\u9178\uff08\u4f8b\uff1a\u03b1-\u30b1\u30c8\u9178\uff09\u306fMSUD\u306e\u8a3a\u65ad\u306b\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n

    \u5f93\u6765\u306f\u751f\u5316\u5b66\u7684\u691c\u67fb\u306e\u307f\u3067MSUD\u8a3a\u65ad\u3068\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u8fd1\u5e74\u3067\u306f\u907a\u4f1d\u5b50\u691c\u67fb<\/strong>\u306e\u91cd\u8981\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002
    MSUD\u3067\u306fBCKD\u8907\u5408\u4f53\u3092\u30b3\u30fc\u30c9\u3059\u308b3\u3064\u306e\u539f\u56e0\u907a\u4f1d\u5b50\uff08BCKDHA\u3001BCKDHB\u3001DBT\uff09\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u306f\u3053\u308c\u30893\u3064\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u89e3\u6790\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

    <\/div>\n\n\n\n
      \n
    1. BCKDHA\u907a\u4f1d\u5b50\uff1a19\u756a\u67d3\u8272\u4f53\u306e19q13.2\u306b\u4f4d\u7f6e\u3057\u3001BCKD E1\u03b1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3092\u30b3\u30fc\u30c9\u3057\u307e\u3059\u3002<\/li>\n\n\n\n
    2. BCKDHB\u907a\u4f1d\u5b50\uff1a6\u756a\u67d3\u8272\u4f53\u306e6q14.1\u306b\u4f4d\u7f6e\u3057\u3001BCKD E1\u03b2\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3092\u30b3\u30fc\u30c9\u3057\u307e\u3059\u3002<\/li>\n\n\n\n
    3. DBT\u907a\u4f1d\u5b50\uff1a1\u756a\u67d3\u8272\u4f53\u306e1p21.2\u306b\u4f4d\u7f6e\u3057\u3001BCKD E2\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3092\u30b3\u30fc\u30c9\u3057\u307e\u3059\u3002<\/li>\n<\/ol>\n\n\n\n
      <\/div>\n\n\n\n

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      \u30ad\u30e3\u30ea\u30a2\u3068\u306f\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u4e00\u65b9\u306b\u5909\u7570\u304c\u3042\u308b\u304c\u3001\u3082\u3046\u4e00\u65b9\u304c\u6b63\u5e38\u3067\u3042\u308b\u305f\u3081\u767a\u75c7\u3057\u306a\u3044\u4eba\u3092\u6307\u3057\u307e\u3059\u3002\u52a3\u6027\u907a\u4f1d\u75c5\u306f\u3001\u30ad\u30e3\u30ea\u30a2\u306e\u4e21\u89aa\u304b\u3089\u306e\u907a\u4f1d\u306b\u3088\u3063\u3066\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u540c\u5909\u7570\u3092\u6301\u3064\u4e8c\u3064\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50\u304c\u63c3\u3046\u5834\u5408(Homozygeous)\u53ca\u3073\u3001\u7570\u306a\u308b\u5909\u7570\u3092\u305d\u308c\u305e\u308c\u4e21\u65b9\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50\u306b\u6301\u3064\u5834\u5408\uff08Compound Heterozygous in trans\uff09\u306b\u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5909\u7570\u90e8\u4f4d\u306e\u7279\u5b9a\u306f\u907a\u4f1d\u5b50\u89e3\u6790\u3084\u907a\u4f1d\u6027\u75be\u60a3\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u91cd\u8981\u3067\u3042\u308a\u3001\u75be\u60a3\u306e\u539f\u56e0\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

      \u3054\u4e21\u89aa\u304cMSUD\u306e\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u5834\u5408\u3001\u6b21\u306e\u3088\u3046\u306a\u9078\u629e\u80a2\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

        \n
      1. \u51fa\u751f\u524d\u8a3a\u65ad\n
          \n
        • \u7f8a\u6c34\u691c\u67fb\n
            \n
          • \u598a\u5a2015\u9031\u76ee\uff08\u5f53\u9662\u3067\u306f17\u9031\u4ee5\u964d\uff09\u4ee5\u964d\u306b\u7f8a\u6c34\u3092\u63a1\u53d6\u3057\u3001\u80ce\u5150\u306eBCKDHA\u3001BCKDHB\u3001DBT\u907a\u4f1d\u5b50\u3092\u89e3\u6790\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n
          • \u7d68\u6bdb\u819c\u63a1\u53d6\uff08CVS\uff09\n
              \n
            • \u598a\u5a2010\u301c13\u9031\u76ee\u306b\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u3001\u80ce\u76e4\u306e\u4e00\u90e8\u3092\u63a1\u53d6\u3057\u3066\u3001\u540c\u69d8\u306b\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u884c\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n
            • \u7121\u4fb5\u8972\u6027\u80ce\u5150\u907a\u4f1d\u5b50\u691c\u67fb\uff08NIPT\uff09\n
                \n
              • \u6bcd\u89aa\u306e\u8840\u6db2\u304b\u3089\u80ce\u5150\u306eDNA\u3092\u691c\u67fb\u3057\u3001\u907a\u4f1d\u5b50\u5909\u7570\u3092\u691c\u51fa\u3057\u307e\u3059\u3002<\/li>\n\n\n\n
              • \u78ba\u5b9a\u8a3a\u65ad\u306e\u305f\u3081\u306b\u306f\u8ffd\u52a0\u306e\u691c\u67fb\u304c\u5fc5\u8981\u3068\u306a\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n\n\n\n
              • \u7740\u5e8a\u524d\u907a\u4f1d\u5b50\u8a3a\u65ad\uff08PGD\/PGT-M\uff09\n
                  \n
                • \u4f53\u5916\u53d7\u7cbe\uff08IVF\uff09\n
                    \n
                  • \u53d7\u7cbe\u5375\u304c\u80da\u76e4\u80de\u306b\u767a\u80b2\u3057\u305f\u6bb5\u968e\u3067\u7d30\u80de\u3092\u63a1\u53d6\u3057\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u884c\u3044\u307e\u3059\u3002<\/li>\n\n\n\n
                  • \u6b63\u5e38\u306a\u907a\u4f1d\u5b50\u3092\u6301\u3064\u80da\u3092\u9078\u3093\u3067\u5b50\u5bae\u306b\u79fb\u690d\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n\n\n\n
                  • \u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\n
                      \n
                    • \u5c02\u9580\u306e\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\n
                        \n
                      • \u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\u306f\u3001\u907a\u4f1d\u5b50\u306e\u30ea\u30b9\u30af\u3001\u691c\u67fb\u65b9\u6cd5\u3001\u598a\u5a20\u306b\u95a2\u3059\u308b\u9078\u629e\u80a2\u3092\u8aac\u660e\u3057\u3001\u592b\u5a66\u304c\u6700\u826f\u306e\u6c7a\u5b9a\u3092\u4e0b\u3059\u305f\u3081\u306e\u30b5\u30dd\u30fc\u30c8\u3092\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n
                        <\/div>\n\n\n\n

                        MSUD\u306f\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u91cd\u7be4\u306a\u4ee3\u8b1d\u75be\u60a3\u3067\u3059\u304c\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3084\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u767a\u75c7\u30ea\u30b9\u30af\u306e\u8a55\u4fa1\u3084\u9069\u5207\u306a\u5bfe\u5fdc\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u3054\u4e21\u89aa\u304c\u30ad\u30e3\u30ea\u30a2\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u308b\u5834\u5408\u3001\u51fa\u751f\u524d\u8a3a\u65ad\u3084\u7740\u5e8a\u524d\u907a\u4f1d\u5b50\u8a3a\u65ad\u3068\u3044\u3063\u305f\u6280\u8853\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u30ea\u30b9\u30af\u3092\u7ba1\u7406\u3057\u3001\u5065\u5eb7\u306a\u304a\u5b50\u69d8\u3092\u6301\u3064\u305f\u3081\u306e\u6e96\u5099\u3092\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002
                        \u4eca\u56de\uff11\u4f8b\u3068\u3057\u3066MSUD\u75c7\u4f8b\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3057\u305f\u304c\u3001\u3053\u306e\u3088\u3046\u306b\u907a\u4f1d\u5b66\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u30d7\u30ec\u30b3\u30f3\u30bb\u30d7\u30b7\u30e7\u30f3\u30b1\u30a2\u3092\u8003\u3048\u308b\u3053\u3068\u306e\u91cd\u8981\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

                        \u4e16\u754c\u7684\u306b\u300c\u30b2\u30ce\u30e0\u30d5\u30a1\u30fc\u30b9\u30c8\u300d\u304c\u63b2\u3052\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u80cc\u666f\u306b\u306f\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u8457\u3057\u3044\u5411\u4e0a\u304c\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002\u4ee5\u524d\u306f\u7279\u5b9a\u907a\u4f1d\u5b50\u306e\u89e3\u6790\u306e\u307f\u3060\u3063\u305f\u3068\u3053\u308d\u304c\u3001\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\uff1c\u5168\u30a8\u30af\u30bd\u30fc\u30e0\u30b7\u30fc\u30b1\u30b7\u30f3\u30b0(WES)\uff1c\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30b7\u30f3\u30b0(WGS)\u304c\u5b9f\u65bd\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0\u90e8\u4f4d\u3001\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u3084\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5236\u5fa1\u7b49\u306b\u3064\u3044\u3066\u3082\u5e45\u5e83\u304f\u89e3\u6790\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u4eca\u307e\u3067\u539f\u56e0\u304c\u7279\u5b9a\u3067\u304d\u306a\u304b\u3063\u305f\u75c7\u4f8b\u306b\u304a\u3044\u3066\u3001\u6570\u5341\u5e74\u304b\u304b\u3063\u3066\u8a3a\u65ad\u304c\u3064\u3044\u305f\u4f8b\u3082\u3042\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u3053\u306e\u3088\u3046\u306a\u89e3\u6790\u304c\u53ef\u80fd\u3068\u306a\u3063\u305f\u3082\u3046\uff11\u3064\u306e\u8981\u56e0\u3068\u3057\u3066\u3001\u8868\u73fe\u578b(Phenotype)\u3068\u907a\u4f1d\u578b(genotype)\u306e\u95a2\u4fc2\u6027\u3092\u7279\u5b9a\u3059\u308b\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u304c\u3069\u3093\u3069\u3093\u69cb\u7bc9\u3055\u308c\u3066\u304d\u305f\u3053\u3068\u306b\u3042\u308a\u307e\u3059\u3002\u73fe\u5728\u3001\u6d77\u5916\u306eNICU\u3067\u306f\u5148\u5929\u6027\u75be\u60a3\u304c\u7591\u308f\u308c\u308b\u5834\u5408\u3001WGS\u304c\u5b9f\u65bd\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u305f\u305d\u3046\u3067\u3059\u3002\u30b2\u30ce\u30e0\u306e\u5168\u9818\u57df\u3092\u8abf\u3079\u3001\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3088\u308a\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8(\u591a\u69d8\u6027)\u3092\u691c\u51fa\u3001\u75c5\u7684\u5909\u7570\u3092\u89e3\u6790\u3057\u307e\u3059\u3002\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3067\u898b\u3064\u304b\u3089\u306a\u3044\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u65b0\u305f\u306b\u30ec\u30dd\u30fc\u30c6\u30a3\u30f3\u30b0\u3055\u308c\u3001\u30c7\u30fc\u30bf\u306e\u84c4\u7a4d\u304c\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

                        \u307e\u3060\u307e\u3060\u8ab2\u984c\u304c\u3042\u308b\u3082\u306e\u306e\u3001\u300c\u30b2\u30ce\u30e0\u30d5\u30a1\u30fc\u30b9\u30c8\u300d\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u751f\u6b96\u533b\u7642\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u3001\u9069\u5207\u306a\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u305f\u308a\u3001\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u3092\u9078\u629e\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u751f\u6b96\u533b\u7642\u306e\u6210\u529f\u7387\u304c\u5411\u4e0a\u3057\u3001\u304a\u5b50\u69d8\u306e\u5065\u5eb7\u3068\u5c06\u6765\u306e\u751f\u6d3b\u306e\u8cea\u304c\u5411\u4e0a\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

                        \u300cGenome First\uff08\u30b2\u30ce\u30e0\u30fb\u30d5\u30a1\u30fc\u30b9\u30c8\uff09\u300d\u3068\u3044\u3046\u8a00\u8449\u3092\u3054\u5b58\u3058\u3067\u3057\u3087\u3046\u304b\u3002\u500b\u3005\u306e\u60a3\u8005\u69d8\u306e\u30b2\u30ce\u30e0 …<\/p>\n","protected":false},"author":1,"featured_media":8258,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"yoast_head":"\n\u30e1\u30fc\u30d7\u30eb\u30b7\u30ed\u30c3\u30d7\u5c3f\u75c7 | \u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.oakclinic-group.com\/blog\/2024\/08\/02\/maple-syrup-urine-disease\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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