{"id":6963,"date":"2021-04-15T11:54:29","date_gmt":"2021-04-15T02:54:29","guid":{"rendered":"https:\/\/www.oakclinic-group.com\/blog\/?p=6963"},"modified":"2021-04-15T11:54:29","modified_gmt":"2021-04-15T02:54:29","slug":"dna%e3%83%a1%e3%83%81%e3%83%ab%e5%8c%96%e3%81%a8%e8%83%9a%e3%81%ae%e8%b3%aa%e3%81%a8%e3%81%ae%e9%96%a2%e9%80%a3","status":"publish","type":"post","link":"https:\/\/www.oakclinic-group.com\/blog\/2021\/04\/15\/dna%e3%83%a1%e3%83%81%e3%83%ab%e5%8c%96%e3%81%a8%e8%83%9a%e3%81%ae%e8%b3%aa%e3%81%a8%e3%81%ae%e9%96%a2%e9%80%a3\/","title":{"rendered":"DNA\u30e1\u30c1\u30eb\u5316\u3068\u80da\u306e\u8cea\u3068\u306e\u95a2\u9023"},"content":{"rendered":"\n

\u691c\u67fb\u90e8\u306e\u5965\u5e73\u3067\u3059\u3002

DNA\u30e1\u30c1\u30eb\u5316\u306f\u3001\u7740\u5e8a\u524d\u306e\u80da\u306e\u767a\u80b2\u904e\u7a0b\u306b\u304a\u3044\u3066\u3001\u7d30\u80de\u304c\u5c06\u6765\u3069\u306e\u7cfb\u7d71\u306b\u5206\u5316\u3059\u308b\u304b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5236\u5fa1\u6a5f\u69cb\u3067\u3059\u3002
\u307e\u305f\u3001DNA\u30e1\u30c1\u30eb\u5316\u306f\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5236\u5fa1\u3057\u3001\u6b63\u5e38\u306a\u767a\u751f\u306b\u4e0d\u53ef\u6b20\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002
\u3053\u308c\u3089\u304b\u3089\u3001\u521d\u671f\u767a\u751f\u306b\u304a\u3044\u3066DNA\u30e1\u30c1\u30eb\u5316\u306f\u91cd\u8981\u3067\u3042\u308a\u3001\u80da\u306e\u30e1\u30c1\u30eb\u5316\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u3001\u80da\u306e\u8cea\u3068\u751f\u6b96\u80fd\u529b\u3092\u53cd\u6620\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002
\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u8ad6\u6587\u3067\u306f\u3001\u80da\u76e4\u80de\u306e\u30e1\u30c1\u30eb\u5316\u30ec\u30d9\u30eb\u3068\u67d3\u8272\u4f53\u500d\u6570\u6027\u3001\u5e74\u9f62\u3001\u80da\u76e4\u80de\u5f62\u6210\u306e\u6642\u671f\u3068\u306e\u76f8\u95a2\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

Evaluation of genome-wide DNA methylation profile of human embryos with different developmental competences
Human Reproduction, deab074, https:\/\/doi.org\/10.1093\/humrep\/deab074<\/p>\n\n\n\n

\u5bfe\u8c61\u30fb\u65b9\u6cd5
\u30e9\u30f3\u30c0\u30e0\u306b\u9078\u3093\u306030\u500b\u306e\u30d2\u30c8\u80da\u76e4\u80de\u304b\u3089\u6804\u990a\u5916\u80da\u8449\u751f\u691c\u30b5\u30f3\u30d7\u30eb\u3092\u63a1\u53d6\u3057\u3066\u3001\u5168\u30b2\u30ce\u30e0\u30d0\u30a4\u30b5\u30eb\u30d5\u30a1\u30a4\u30c8\u30b7\u30fc\u30b1\u30f3\u30b9\uff08WGBS\uff09\u3092\u884c\u3044\u3001DNA\u30e1\u30c1\u30eb\u5316\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002
\u80da\u306e\u540c\u4e00\u6027\u3092\u5171\u5909\u91cf\u3068\u3057\u3066\u3001DNA\u30e1\u30c1\u30eb\u5316\u30ec\u30d9\u30eb\u3068\u3001\u500d\u6570\u6027\u306e\u72b6\u614b\uff08\u7570\u6570\u6027\uff08n = 20\uff09\u3068\u500d\u6570\u6027\uff08n = 10\uff09\uff09\u3001\u5973\u6027\u306e\u5e74\u9f62\uff0829.4\u201042.5\u6b73\uff09\u3001\u80da\u76e4\u80de\u5f62\u6210\u306e\u6642\u671f\uff08day 5\uff08n = 16\uff09\u3068day 6\uff08n =14\uff09\uff09\u3068\u306e\u9593\u306e\u95a2\u9023\u3092\u3001\u30cd\u30b9\u30c8\u7dda\u5f62\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u89e3\u6790\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u7d50\u679c
\u7570\u6570\u6027\u80da\u306f\u3001\u500d\u6570\u6027\u80da\u306b\u6bd4\u3079\u3066\u3001\u30b2\u30ce\u30e0\u5168\u4f53\u306eDNA\u30e1\u30c1\u30eb\u5316\u30ec\u30d9\u30eb\u304c\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u4e2d\u592e\u502425.4\uff05\u00b13.2\uff05 vs. 24.7\uff05\u00b13.2\uff05\u3001P < 0.005\uff09\u3002
\u80da\u76e4\u80de\u306e\u30b2\u30ce\u30e0\u5168\u4f53\u306eDNA\u30e1\u30c1\u30eb\u5316\u30ec\u30d9\u30eb\u306f\u3001\u5973\u6027\u306e\u5e74\u9f62\u3068\u3068\u3082\u306b\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\uff08P < 0.0001\uff09\u3002
day 5\u3068day 6\u306e\u80da\u76e4\u80de\u306e\u9593\u3067\u306f\u3001DNA\u30e1\u30c1\u30eb\u5316\u30ec\u30d9\u30eb\u306b\u6709\u610f\u306a\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u4e2d\u592e\u502425.2%\u00b13.8% vs. 26.1%\u00b12.9%\u3001P = 0.99\uff09\u3002
\u67d3\u8272\u4f53\u5358\u4f4d\u3067\u898b\u308b\u3068\u3001\u30e2\u30ce\u30bd\u30df\u30fc\u80da\u3067\u306f\u95a2\u4e0e\u3059\u308b\u67d3\u8272\u4f53\uff08-4, -13, -16, -17, -21, -22\uff09\u306e\u30e1\u30c1\u30eb\u5316\u30ec\u30d9\u30eb\u304c\u4f4e\u3044\uff08P < 0.0001\uff09\u306e\u306b\u5bfe\u3057\u3001\u30c8\u30ea\u30bd\u30df\u30fc\u80da\u3067\u306f\u95a2\u4e0e\u3059\u308b\u67d3\u8272\u4f53\uff08+7, +13, +15, +19, +21\uff09\u306b\u30e1\u30c1\u30eb\u5316\u306e\u5897\u52a0\u3082\u6e1b\u5c11\u3082\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\uff08P = 0.96\uff09\u3002<\/p>\n\n\n\n

\u89e3\u8aac
\u7740\u5e8a\u524d\u306e\u767a\u751f\u904e\u7a0b\u3067\u8d77\u3053\u308b\u30b2\u30ce\u30e0\u5168\u4f53\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u306f\u3001\u53d7\u7cbe\u3068\u540c\u6642\u306b\u59cb\u307e\u308a\u3001\u80da\u76e4\u80de\u5f62\u6210\u307e\u3067\u7d9a\u304d\u307e\u3059\u3002
\u3053\u308c\u306f\u3001\u6b63\u5e38\u306a\u80da\u304a\u3088\u3073\u80ce\u5150\u306e\u767a\u9054\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002
\u521d\u671f\u767a\u751f\u306b\u304a\u3051\u308bDNA\u30e1\u30c1\u30eb\u5316\u3092\u4ecb\u3057\u305f\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5236\u5fa1\u306e\u91cd\u8981\u6027\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u767a\u751f\u80fd\u529b\u306e\u7570\u306a\u308b\u80da\u304c\u80da\u76e4\u80de\u671f\u306b\u7570\u306a\u308bDNA\u30e1\u30c1\u30eb\u5316\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u793a\u3059\u304b\u3069\u3046\u304b\u306f\u3001\u3053\u308c\u307e\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002
\u672c\u7814\u7a76\u306b\u3088\u308a\u3001\u80da\u76e4\u80de\u306e\u6804\u990a\u5916\u80da\u8449\u306e\u30e1\u30c1\u30eb\u5316\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3068\u67d3\u8272\u4f53\u7570\u6570\u6027\u304a\u3088\u3073\u6bcd\u4f53\u5e74\u9f62\u3068\u306e\u76f8\u95a2\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002
\u307e\u305f\u3001day 5\u3068day 6\u306e\u80da\u306e\u30e1\u30c1\u30eb\u5316\u30ec\u30d9\u30eb\u306b\u5dee\u304c\u306a\u3044\u3068\u3044\u3046\u7d50\u679c\u306f\u3001\u6210\u9577\u901f\u5ea6\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u80da\u76e4\u80de\u671f\u306b\u5230\u9054\u3057\u305f\u80da\u306f\u3001\u540c\u69d8\u306e\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u3092\u9054\u6210\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002
\u4eca\u56de\u306e\u7d50\u679c\u304b\u3089\u3001\u30b2\u30ce\u30e0\u5168\u4f53\u306e\u30e1\u30c1\u30eb\u5316\u30ec\u30d9\u30eb\u304c\u80da\u306e\u8cea\u3068\u8ca0\u306e\u76f8\u95a2\u95a2\u4fc2\u306b\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002
\u3057\u304b\u3057\u3001\u4eca\u56de\u7528\u3044\u305f\u624b\u6cd5\u3092\u80da\u306e\u80fd\u529b\u8a55\u4fa1\u306b\u5b9f\u7528\u5316\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3088\u308a\u591a\u304f\u306e\u80da\u3067WGBS\u89e3\u6790\u3092\u884c\u3044\u3001\u7740\u5e8a\u3084\u751f\u5150\u306e\u8a95\u751f\u3068\u306e\u76f8\u95a2\u3092\u5177\u4f53\u7684\u306b\u691c\u8a0e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n","protected":false},"excerpt":{"rendered":"

\u691c\u67fb\u90e8\u306e\u5965\u5e73\u3067\u3059\u3002 DNA\u30e1\u30c1\u30eb\u5316\u306f\u3001\u7740\u5e8a\u524d\u306e\u80da\u306e\u767a\u80b2\u904e\u7a0b\u306b\u304a\u3044\u3066\u3001\u7d30\u80de\u304c\u5c06\u6765\u3069\u306e\u7cfb\u7d71\u306b\u5206\u5316\u3059\u308b\u304b\u306b …<\/p>\n","protected":false},"author":1,"featured_media":6708,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"yoast_head":"\nDNA\u30e1\u30c1\u30eb\u5316\u3068\u80da\u306e\u8cea\u3068\u306e\u95a2\u9023 | \u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.oakclinic-group.com\/blog\/2021\/04\/15\/dna\u30e1\u30c1\u30eb\u5316\u3068\u80da\u306e\u8cea\u3068\u306e\u95a2\u9023\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DNA\u30e1\u30c1\u30eb\u5316\u3068\u80da\u306e\u8cea\u3068\u306e\u95a2\u9023 | \u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0\" \/>\n<meta property=\"og:description\" content=\"\u691c\u67fb\u90e8\u306e\u5965\u5e73\u3067\u3059\u3002 DNA\u30e1\u30c1\u30eb\u5316\u306f\u3001\u7740\u5e8a\u524d\u306e\u80da\u306e\u767a\u80b2\u904e\u7a0b\u306b\u304a\u3044\u3066\u3001\u7d30\u80de\u304c\u5c06\u6765\u3069\u306e\u7cfb\u7d71\u306b\u5206\u5316\u3059\u308b\u304b\u306b …\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.oakclinic-group.com\/blog\/2021\/04\/15\/dna\u30e1\u30c1\u30eb\u5316\u3068\u80da\u306e\u8cea\u3068\u306e\u95a2\u9023\/\" \/>\n<meta property=\"og:site_name\" content=\"\u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0\" \/>\n<meta property=\"article:publisher\" 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