{"id":6805,"date":"2021-01-21T13:38:00","date_gmt":"2021-01-21T04:38:00","guid":{"rendered":"https:\/\/www.oakclinic-group.com\/blog\/?p=6805"},"modified":"2021-01-21T13:38:00","modified_gmt":"2021-01-21T04:38:00","slug":"%e6%97%a9%e7%99%ba%e5%8d%b5%e5%b7%a3%e4%b8%8d%e5%85%a8%ef%bc%88poi%ef%bc%89%e3%81%ae%e6%96%b0%e8%a6%8f%e3%83%9e%e3%83%bc%e3%82%ab%e3%83%bc","status":"publish","type":"post","link":"https:\/\/www.oakclinic-group.com\/blog\/2021\/01\/21\/%e6%97%a9%e7%99%ba%e5%8d%b5%e5%b7%a3%e4%b8%8d%e5%85%a8%ef%bc%88poi%ef%bc%89%e3%81%ae%e6%96%b0%e8%a6%8f%e3%83%9e%e3%83%bc%e3%82%ab%e3%83%bc\/","title":{"rendered":"\u65e9\u767a\u5375\u5de3\u4e0d\u5168\uff08POI\uff09\u306e\u65b0\u898f\u30de\u30fc\u30ab\u30fc"},"content":{"rendered":"\n

\u80da\u57f9\u990a\u58eb\u306e\u5965\u5e73\u88d5\u4e00\u3067\u3059\u3002<\/p>\n\n\n\n

\u65e9\u767a\u5375\u5de3\u4e0d\u5168\uff08POI\uff09\u306f\u300140\u6b73\u524d\u306b\u5375\u5de3\u6a5f\u80fd\u304c\u505c\u6b62\u3059\u308b\u3053\u3068\u3067\u5b9a\u7fa9\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u72b6\u614b\u306f\u3001FSH\u306e\u4e0a\u6607\uff08FSH > 25 IU \/ L\uff09\u304a\u3088\u3073\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u6b20\u4e4f\u3092\u4f34\u3046\u7121\u6708\u7d4c\u307e\u305f\u306f\u7a00\u767a\u6708\u7d4c\uff08\u6708\u7d4c\u306e\u983b\u5ea6\u304c\u5c11\u306a\u3044\uff09\u3092\u7279\u5fb4\u3068\u3057\u307e\u3059\u3002\u4e00\u822c\u7684\u306a\u751f\u6b96\u5185\u5206\u6ccc\u969c\u5bb3\u3067\u3042\u308bPOI\u306f\u3001\u751f\u6b96\u5e74\u9f62\u306b\u3042\u308b\u5973\u6027\u306e\u7d041\uff5e5\uff05\u304c\u7f79\u60a3\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001POI\u306b\u304a\u3051\u308b\u5375\u5de3\u6a5f\u80fd\u3092\u4e88\u6e2c\u30fb\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u3001\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u3001AMH\u3001\u30a4\u30f3\u30d2\u30d3\u30f3B\u306a\u3069\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u8ad6\u6587\u3067\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u56e0\u5b503\uff08INSL3\uff09\u306b\u7740\u76ee\u3057\u3001\u5375\u5de3\u6a5f\u80fd\u306e\u65b0\u305f\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u3092\u8abf\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

New theca-cell marker insulin-like factor 3 is associated with premature ovarian insufficiency<\/p>\n\n\n\n

Fertility and Sterility, DOI:https:\/\/doi.org\/10.1016\/j.fertnstert.2020.08.005<\/p>\n\n\n\n

\u5bfe\u8c61\u30fb\u65b9\u6cd5<\/p>\n\n\n\n

2017\u5e74\u304b\u30892019\u5e74\u306e\u9593\u306b\u300148\u4eba\u306ePOI\u60a3\u8005\uff0825 IU\/L < FSH \u2264 40 IU\/L\uff09\u300149\u4eba\u306e\u751f\u5316\u5b66\u7684POI\u60a3\u8005\uff08bPOI\u60a3\u8005\u300110 IU\/L < FSH \u2264 25 IU\/L\uff09\u300148\u4eba\u306e\u6b63\u5e38\u306a\u5375\u5de3\u4e88\u5099\u80fd\u3092\u6301\u3064\u5973\u6027\uff08\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3001FSH < 10 IU\/L\uff09\u3092\u5bfe\u8c61\u306b\u3057\u305f\u5f8c\u308d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u3059\u3002\u3061\u306a\u307f\u306bbPOI\u306f\u4e00\u822c\u7684\u306bPOI\u306e\u524d\u5146\u6bb5\u968e\u3068\u898b\u306a\u3055\u308c\u3001\u898f\u5247\u7684\u307e\u305f\u306f\u4e0d\u898f\u5247\u306a\u6708\u7d4c\u304a\u3088\u3073FSH\u30ec\u30d9\u30eb\u306e\u4e0a\u6607\u3068\u5b9a\u7fa9\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5404\u30b0\u30eb\u30fc\u30d7\u306b\u304a\u3044\u3066\u3001\u8840\u6e05\u304a\u3088\u3073\u5375\u80de\u6db2\u4e2d\u306eINSL3\u306e\u30ec\u30d9\u30eb\u3001\u5404\u5375\u5de3\u4e88\u5099\u80fd\u30de\u30fc\u30ab\u30fc\uff08FSH\u3001LH\u3001AMH\u3001\u30a4\u30f3\u30d2\u30d3\u30f3B\u3001E2<\/sub>\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3001\u80de\u72b6\u5375\u80de\u6570\uff08AFC\uff09\uff09\u3068\u306e\u95a2\u9023\u3092\u8abf\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u7d50\u679c<\/p>\n\n\n\n

\u5408\u8a08145\u4eba\u306e\u7814\u7a76\u53c2\u52a0\u5973\u6027\u306e\u5e73\u5747\u5e74\u9f62\u306f31.05\u00b13.12\u6b73\uff0822\uff5e39\u6b73\uff09\u3067\u3057\u305f\u30023\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u5e74\u9f62\u304a\u3088\u3073\u4f53\u91cd\u6307\u6570\uff08BMI\uff09\u306b\u6709\u610f\u306a\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\uff08P > 0.05\uff09\u3002\u5375\u5de3\u6a5f\u80fd\u4e0d\u5168\u306e\u9032\u884c\u306b\u4f34\u3044\u3001FSH\u3068LH\u306e\u30ec\u30d9\u30eb\u306f\u5897\u52a0\u3057\u3001AMH\u3001\u30a4\u30f3\u30d2\u30d3\u30f3B\u3001E2<\/sub>\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3001AFC\u306f\u4f4e\u4e0b\u3057\u307e\u3057\u305f\uff08P < 0.001\uff09\u3002<\/p>\n\n\n\n

\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u306e\u5973\u6027\uff08412.02 \u00b1 155.81 pg\/mL\uff09\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001bPOI\u60a3\u8005\uff08291.86 \u00b1 97.68 pg\/mL\u3001P < 0.001\uff09\u304a\u3088\u3073POI\u60a3\u8005\uff08179.40 \u00b1 74.17 pg\/mL\u3001P < 0.001\uff09\u3067\u306f\u3001INSL3\u30ec\u30d9\u30eb\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u306e\u5973\u6027\u306eINSL3\u30ec\u30d9\u30eb\u306e95\uff05\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u3092\u300c\u6b63\u5e38\u300d\u7bc4\u56f2\u3068\u3057\u305f\u3068\u3053\u308d\u3001bPOI\u60a3\u8005\u306e82\uff05\uff0848\u4eba\u4e2d40\u4eba\uff09\u3068POI\u60a3\u8005\u306e98\uff05\uff0849\u4eba\u4e2d48\u4eba\uff09\u3067INSL3\u30ec\u30d9\u30eb\u304c\u6b63\u5e38\u4ee5\u4e0b\u306b\u4f4e\u4e0b\u3057\u305f\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u5375\u80de\u6db2\u4e2d\u306eINSL3\u30ec\u30d9\u30eb\u306b\u3064\u3044\u3066\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3068bPOI\u60a3\u8005\u7fa4\u3067\u6bd4\u8f03\u3057\u3066\u3044\u307e\u3059\u3002\u5375\u80de\u6db2\u4e2d\u306eINSL3\u30ec\u30d9\u30eb\u306f\u3001\u8840\u6e05\u3068\u6bd4\u3079\u3066\u7d046\u500d\u3082\u9ad8\u3044\u5024\u3068\u306a\u308a\u307e\u3057\u305f\u304c\u3001\u4e21\u7fa4\u9593\u3067\u6709\u610f\u306a\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\uff08P=0.241\uff09\u3002<\/p>\n\n\n\n

\u8840\u4e2dINSL3\u30ec\u30d9\u30eb\u3068FSH\uff08-0.6552\u3001P < 0.001\uff09\u304a\u3088\u3073LH\uff08-0.4328\u3001P < 0.001\uff09\u306f\u8ca0\u306e\u76f8\u95a2\u304c\u3042\u308a\uff08INSL3\u30ec\u30d9\u30eb\u304c\u9ad8\u3044\u3068FSH\u304a\u3088\u3073LH\u5024\u304c\u4f4e\u3044\uff09\u3001AMH\uff080.6175\u3001P < 0.001\uff09\u3001\u30a4\u30f3\u30d2\u30d3\u30f3B\uff080.4007\u3001P < 0.001\uff09\u3001AFC\uff080.6305\u3001P < 0.001\uff09\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff080.1809\u3001P < 0.0365\uff09\u306f\u6b63\u306e\u76f8\u95a2\u304c\u3042\u308a\u307e\u3057\u305f\uff08INSL3\u30ec\u30d9\u30eb\u304c\u9ad8\u3044\u3068\u3053\u308c\u3089\u306e\u5024\u3082\u9ad8\u3044\uff09\u3002\u4e00\u65b9\u3001E2<\/sub>\u3068\u306f\u7d71\u8a08\u4e0a\u6709\u610f\u306a\u76f8\u95a2\u306f\u307f\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\uff080.1581\u3001P=0.0621\uff09\u3002<\/p>\n\n\n\n

\u3055\u3089\u306b\u3001\u8840\u4e2dINSL3\u30ec\u30d9\u30eb\u306fPOI\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u306a\u308a\u5f97\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u89e3\u8aac<\/p>\n\n\n\n

INSL3\u306f\u3001\u80de\u72b6\u5375\u80de\u306e\u5185\u83a2\u819c\u7d30\u80de\uff08\u5375\u80de\u306e\u5916\u5074\u306b\u5b58\u5728\u3057\u3001\u30a2\u30f3\u30c9\u30ed\u30b8\u30a7\u30f3\u306e\u7523\u751f\u306b\u95a2\u308f\u308b\u7d30\u80de\uff09\u3068\u9ec4\u4f53\u3067\u5408\u6210\u3055\u308c\u307e\u3059\u3002INSL3 \u30b7\u30b0\u30ca\u30eb\u306f\u3001\u30a2\u30f3\u30c9\u30ed\u30b8\u30a7\u30f3\u5408\u6210\u3092\u8abf\u7bc0\u3057\u3001\u80de\u72b6\u5375\u80de\u306e\u6210\u9577\u3068\u6a5f\u80fd\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002INSL3\u3092\u6b20\u640d\u3057\u305f\u96cc\u30de\u30a6\u30b9\u3067\u306f\u3001\u7d30\u80de\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3068\u5375\u80de\u9589\u9396\u306e\u5897\u52a0\u3092\u4f34\u3046\u4e0d\u598a\u75c7\u3092\u793a\u3057\u307e\u3059\u3002\u307e\u305f\u3001INSL3\u30ec\u30d9\u30eb\u304c\u80de\u72b6\u5375\u80de\u6570\u3068\u6b63\u306e\u76f8\u95a2\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001INSL3\u306f\u3001\u521d\u671f\u306e\u5375\u80de\u767a\u80b2\u3068\u5375\u5de3\u5fae\u5c0f\u74b0\u5883\u3067\u306e\u6a5f\u80fd\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u521d\u3081\u3066POI\u306e\u5973\u6027\u306b\u304a\u3051\u308b INSL3 \u306e\u6b20\u4e4f\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u8840\u4e2dINSL3\u304cPOI\u306e\u6709\u671b\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u5375\u80de\u767a\u80b2\u306e\u5236\u5fa1\u3084\u30b9\u30c6\u30ed\u30a4\u30c9\u5408\u6210\u3001POI\u306e\u75c5\u614b\u306b\u95a2\u3059\u308bINSL3\u306e\u8a73\u7d30\u306a\u5f79\u5272\u306e\u89e3\u660e\u306b\u3064\u3044\u3066\u306f\u4eca\u5f8c\u306e\u7814\u7a76\u306b\u671f\u5f85\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u80da\u57f9\u990a\u58eb\u306e\u5965\u5e73\u88d5\u4e00\u3067\u3059\u3002 \u65e9\u767a\u5375\u5de3\u4e0d\u5168\uff08POI\uff09\u306f\u300140\u6b73\u524d\u306b\u5375\u5de3\u6a5f\u80fd\u304c\u505c\u6b62\u3059\u308b\u3053\u3068\u3067\u5b9a\u7fa9\u3055\u308c\u307e\u3059\u3002 …<\/p>\n","protected":false},"author":1,"featured_media":3104,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"yoast_head":"\n\u65e9\u767a\u5375\u5de3\u4e0d\u5168\uff08POI\uff09\u306e\u65b0\u898f\u30de\u30fc\u30ab\u30fc | \u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.oakclinic-group.com\/blog\/2021\/01\/21\/\u65e9\u767a\u5375\u5de3\u4e0d\u5168\uff08poi\uff09\u306e\u65b0\u898f\u30de\u30fc\u30ab\u30fc\/\" \/>\n<meta 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