{"id":2459,"date":"2013-04-09T19:29:00","date_gmt":"2013-04-09T10:29:00","guid":{"rendered":"https:\/\/www.oakclinic-group.com\/blog\/?p=2459"},"modified":"2020-07-15T14:38:34","modified_gmt":"2020-07-15T05:38:34","slug":"kitaya-30","status":"publish","type":"post","link":"https:\/\/www.oakclinic-group.com\/blog\/2013\/04\/09\/kitaya-30\/","title":{"rendered":"\u7740\u5e8a\u306b\u5fc5\u8981\u306a\u5b50\u5bae\u5185\u819c\u306e\u708e\u75c7\u3068\u306f\u2026\u305d\u306e5"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignright size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2020\/03\/150107_office.jpg\" alt=\"\" class=\"wp-image-1452\" width=\"230\"\/><\/figure><\/div>\n\n\n\n<p>\uff08\u300c\u7740\u5e8a\u306b\u5fc5\u8981\u306a\u5b50\u5bae\u5185\u819c\u306e\u708e\u75c7\u3068\u306f\u2026\u305d\u306e4\u300d\u306f<a href=\"https:\/\/www.oakclinic-group.com\/blog\/2012\/05\/14\/kitaya-57\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (\u65b0\u3057\u3044\u30bf\u30d6\u3067\u958b\u304f)\">\u3053\u3061\u3089<\/a>\u3067\u3059\u3002\uff09<\/p>\n\n\n\n<p>\u533b\u5c40\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u80da\u76e4\u80de\u306f\u3001\u5206\u5272\u30fb\u62e1\u5f35\u306b\u3068\u3082\u306a\u3063\u3066\u3001\u8d64\u3061\u3083\u3093\u306b\u306a\u308b\u7d30\u80de\u306e\u30b0\u30eb\u30fc\u30d7(\u5185\u7d30\u80de\u584a)\u3068\u80ce\u76e4\u306b\u306a\u308b\u7d30\u80de\u306e\u30b0\u30eb\u30fc\u30d7(\u6804\u990a\u5916\u80da\u8449)\u3068\u306b\u5206\u304b\u308c\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u300c\u80da\u304c\u5b50\u5bae\u5185\u819c\u306b\u5bfe\u3057\u3066\u6b63\u3057\u3044\u5411\u304d\u306b\u7740\u5e8a\u3059\u308b\u300d\u305f\u3081\u306b\u306f\u3001\u80ce\u76e4\u306b\u306a\u308b\u90e8\u5206\u304c\u5b50\u5bae\u5185\u819c\u5074\u306b\u3001\u8d64\u3061\u3083\u3093\u306b\u306a\u308b\u90e8\u5206\u304c\u5b50\u5bae\u8154\uff08\u5b50\u5bae\u306e\u30b9\u30da\u30fc\u30b9\u5074\uff09\u306b\u914d\u7f6e\u3055\u308c\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3092\u5bfe\u7f6e(apposition)\u3068\u547c\u3073\u307e\u3059\u3002<br>\u5b50\u5bae\u5185\u3067\u80da\u76e4\u80de\u304c\u5b50\u5bae\u5185\u819c\u306b\u5bfe\u3057\u3066\u6b63\u3057\u304f\u5411\u304b\u3044\u5408\u3046\u73fe\u8c61\u3067\u3001\u80da\u306e\u7740\u5e8a\u306e\u7b2c\u4e00\u6bb5\u968e\u3067\u3059\u3002<br>\u3061\u306a\u307f\u306b\u3001\u7b2c\u4e8c\u6bb5\u968e\u304c\u63a5\u7740\u3001\u7b2c\u4e09\u6bb5\u968e\u3092\u4fb5\u5165\u30683\u3064\u306e\u30b9\u30c6\u30c3\u30d7\u306b\u5206\u3051\u3066\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5bfe\u7f6e\u306b\u3064\u3044\u3066\u306f\u3001\u80da\u7740\u5e8a\u4e09\u6bb5\u968e\u306e\u4e2d\u3067\u6700\u3082\u7814\u7a76\u304c\u9045\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u4eca\u56de\u3001\u30a4\u30b9\u30e9\u30a8\u30eb\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3088\u308a\u8208\u5473\u6df1\u3044\u5831\u544a\u304c\u3042\u308a\u307e\u3057\u305f\u3002(Sela HY et al. Placenta 2013;34(3):222-30.)<\/p>\n\n\n\n<p>CXCL10\u3068\u3044\u3046\u708e\u75c7\u6027\u86cb\u767d\u304c\u5bfe\u7f6e\u306b\u95a2\u308f\u308b\u5019\u88dc\u86cb\u767d\u3060\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002<br>\u5b50\u5bae\u5185\u819c\u7d30\u80de\u3067\u4f5c\u3089\u308c\u3066\u3001\u5c06\u6765\u80ce\u76e4\u306b\u306a\u308b\u7d30\u80de\u3084\u521d\u671f\u306e\u80ce\u76e4\u7d30\u80de\u306b\u50cd\u304d\u304b\u3051\u3066\u3001\u3053\u308c\u3089\u306e\u7d30\u80de\u306e\u904b\u52d5\u6027\u304c\u5897\u3059\u3053\u3068\u3002<\/p>\n\n\n\n<p>\u3064\u307e\u308a\u3001\u5b50\u5bae\u5185\u819c\u5074\u306b\u5c06\u6765\u80ce\u76e4\u304c\u914d\u7f6e\u3055\u308c\u308b\u3088\u3046\u8abf\u6574\u5f79\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u3001\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>CXCL10\u306b\u3064\u3044\u3066\u306f\u3001\u4ee5\u524d\u306b\u5225\u306e\u76ee\u7684\u3067\u8abf\u3079\u3066\u3044\u305f\u3053\u3068\u304c\u3042\u3063\u3066\u3001\u5897\u6b96\u671f\uff08\u6392\u5375\u524d\uff09\u306b\u6bd4\u3079\u3066\u5206\u6ccc\u4e2d\u671f\u30fb\u5f8c\u671f\uff08\u7740\u5e8a\u671f\uff09\u306b\u5b50\u5bae\u5185\u819c\u542b\u6709\u91cf\u304c\u5927\u5e45\u306b\u5897\u52a0\u3059\u308b\u86cb\u767d\u3067\u3059\u3002<br>\u307e\u305f\u3053\u306e\u6392\u5375\u5f8c\u306e\u5b50\u5bae\u5185\u819c\u3067\u306eCXCL10\u306e\u5897\u52a0\u306b\u306f\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\uff08\u9ec4\u4f53\u30db\u30eb\u30e2\u30f3\uff09\u304c\u5927\u304d\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f (Kitaya K et al. J Clin Endocrinol Metab. 2004;89(5):2470-6)\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u5973\u6027\u5074\u306b\u3068\u3063\u3066\u534a\u5206\u306f\u7570\u7269\u3067\u3042\u308b\u80da\u76e4\u80de\u3092\u53d7\u3051\u5165\u308c\u308b\u305f\u3081\u306b\u3001\u7740\u5e8a\u671f\u5b50\u5bae\u5185\u819c\u3067\u306f\u4ed6\u306e\u81d3\u5668\u3067\u306f\u898b\u3089\u308c\u306a\u3044\u3001\u6fc0\u3057\u3044\u5730\u6bbb\u5909\u52d5\u304c\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u304c\u7aba\u3048\u307e\u3059\u3002 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