{"id":2089,"date":"2013-11-12T17:08:00","date_gmt":"2013-11-12T08:08:00","guid":{"rendered":"https:\/\/www.oakclinic-group.com\/blog\/?p=2089"},"modified":"2020-07-08T17:48:48","modified_gmt":"2020-07-08T08:48:48","slug":"kitaya-16","status":"publish","type":"post","link":"https:\/\/www.oakclinic-group.com\/blog\/2013\/11\/12\/kitaya-16\/","title":{"rendered":"ASRM2013 \u80da\u7740\u5e8a\u30fb\u7740\u5e8a\u969c\u5bb3\u95a2\u9023\u30c8\u30d4\u30c3\u30af\u30b9\u2026\u305d\u306e1"},"content":{"rendered":"\n<p>\u533b\u5c40\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\u3067\u3059\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2014\/05\/928533_s.jpg\" alt=\"\" class=\"wp-image-5493\" width=\"400\" srcset=\"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2014\/05\/928533_s.jpg 640w, https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2014\/05\/928533_s-300x200.jpg 300w, https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2014\/05\/928533_s-270x180.jpg 270w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n\n<p>\u65e9\u901f\u7d39\u4ecb\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>1.\u300c\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30c7\u30a3\u30f3\u306e\u4ef2\u9593\u30fb\u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\u304c\u4f53\u5916\u53d7\u7cbe\uff0d\u80da\u79fb\u690d\u306b\u3088\u308b\u598a\u5a20\u7387\u3092\u4e0a\u3052\u308b\u300d<\/strong><\/p>\n\n\n\n<p>\u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\u88fd\u5264\u3092\u6dfb\u52a0\u3057\u305f\u80da\u57f9\u990a\u6db2\u3092\u7528\u3044\u305f\u3068\u3053\u308d\u3001\u7121\u6dfb\u52a0\u57f9\u990a\u6db2\u3088\u308a\u3082\u81e8\u5e8a\u598a\u5a20\u7387\u304c\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\u3068\u3044\u3046\u3082\u306e\u3067\u3001\u4ee5\u524d\u306b\u3082\u5831\u544a\u304c\u3042\u308a\u307e\u3057\u305f\u304c(Huang JC et al., Hum Reprod 2014;19:1856-60\u306a\u3069)\u3001\u4eca\u56de\u306e\u7b2c\uff11\u76f8\u81e8\u5e8a\u8a66\u9a13\u3067\u3082\u3084\u306f\u308a\u52b9\u679c\u3092\u8a8d\u3081\u305f\u3088\u3046\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30c7\u30a3\u30f3\u985e\u306f\u7740\u5e8a\u306b\u5fc5\u9808\u3068\u3055\u308c\u308b\u4e00\u65b9\u3067\u3001\u5b50\u5bae\u53ce\u7e2e\u3001\u6708\u7d4c\u3001\u6d41\u7523\u3001\uff08\u3082\u3057\u304b\u3059\u308b\u3068\u7740\u5e8a\u4e0d\u5168\uff09\u306b\u3082\u3001\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u96e3\u3057\u3044\u5206\u5b50\u3067\u3059\u3002\u91cf\u306e\u591a\u3044\u5c11\u306a\u3044\u3067\u598a\u5a20\u306b\u5bfe\u3059\u308b\u4f5c\u7528\u304c\u5909\u308f\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<br>\u305d\u306e\u4e2d\u3067\u3001\u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\u306f\u5375\u7ba1\u3067\u5927\u91cf\u306b\u4f5c\u3089\u308c\u308b\u5206\u5b50\u3067\u3001\u4eca\u5f8c\u306e\u8ffd\u8a66\u306b\u671f\u5f85\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>2.\u300c\u67d3\u8272\u4f53\u6b63\u5e38\u80da\u306e\u4e2d\u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u5c11\u306a\u3044\u3082\u306e\u306f\u3001\u591a\u3044\u3082\u306e\u3088\u308a\u81e8\u5e8a\u598a\u5a20\u7387\u304c\u9ad8\u304b\u3063\u305f\u300d<\/strong><\/p>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306fAMP\u5408\u6210\u3001\u7d30\u80de\u547c\u5438\u3092\u306f\u3058\u3081\u3068\u3057\u3066\u591a\u6570\u306e\u751f\u547d\u73fe\u8c61\u306b\u7121\u304f\u3066\u306f\u306a\u3089\u306a\u3044\u7d30\u80de\u306e\u4e2d\u306e\u90e8\u54c1\u3067\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u6838\u3068\u306f\u7570\u306a\u308b\u72ec\u81ea\u306eDNA\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<br>\u7cbe\u5b50\u7531\u6765\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u3001\u901a\u5e38\u306f\u53d7\u7cbe\u5f8c\u306b\u6392\u9664\u3055\u308c\u3066\u3057\u307e\u3046\u305f\u3081\u5b50\u306f\u6bcd\u65b9\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u3092\u53d7\u3051\u7d99\u304e\u307e\u3059\u3002\uff08\u5c0f\u8aac\u300c\u30d1\u30e9\u30b5\u30a4\u30c8\u30fb\u30a4\u30d6\u300d\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u30c6\u30fc\u30de\u306b\u3057\u3066\u3044\u307e\u3059\uff09<\/p>\n\n\n\n<p>\u3053\u306e\u82f1\u56fd\u304b\u3089\u306e\u5831\u544a\u3067\u306f\u3001\u6700\u7d42\u7684\u306b\u67d3\u8272\u4f53\u6b63\u5e38\u80da\u306e\u307f\u3092\u9078\u3093\u3067\u6bd4\u8f03\u3057\u3066\u3044\u307e\u3059\u3002<br>\u56fd\u5185\u3067\u306f\u307e\u3060\u4e00\u90e8\u306b\u306e\u307f\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u7740\u5e8a\u524d\u8a3a\u65ad\u304c\u3059\u3079\u3066\u306b\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u5c11\u306a\u3044\u80da\u307b\u3069\u7d30\u80de\u3078\u306e\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u597d\u307e\u3057\u3044\u74b0\u5883\u306b\u3042\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u7d50\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>3.\u300c\u767d\u8840\u75c5\u6291\u5236\u56e0\u5b50(LIF)\u907a\u4f1d\u5b50\u306e\u4e00\u5869\u57fa\u591a\u578b\u306f\u7740\u5e8a\u4e0d\u5168\u3068\u306f\u7121\u95a2\u4fc2\u3068\u8003\u3048\u3089\u308c\u308b\u300d<\/strong><\/p>\n\n\n\n<p>LIF\u306e\u8a73\u7d30\u306b\u3064\u3044\u3066\u306f2012-05-11\u306e\u30d6\u30ed\u30b0\u8a18\u4e8b\u3082\u53c2\u7167\u304f\u3060\u3055\u3044\u3002\u7740\u5e8a\u4e0d\u5168\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u4e00\u6642\u306f\u5927\u304d\u304f\u671f\u5f85\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u5f8c\u306e\u81e8\u5e8a\u6210\u7e3e\u304c\u597d\u307e\u3057\u304f\u306a\u304f\u3001\u73fe\u5728\u4f7f\u7528\u306b\u306f\u81f3\u3063\u3066\u304a\u308a\u307e\u305b\u3093\u3002<br>\u4e00\u65b9\u3067\u3001LIF\u306e\u963b\u5bb3\u5264\uff08\u50cd\u304d\u3092\u6b62\u3081\u308b\u85ac\uff09\u306b\u7740\u5e8a\u3092\u9632\u3050\u52b9\u679c\u304c\u3042\u308a\u3001\u907f\u598a\u85ac\u3068\u3057\u3066\u6709\u52b9\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u8ad6\u6587\u304c\u6700\u8fd1\u8907\u6570\u51fa\u3066\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>LIF\u907a\u4f1d\u5b50\u306eT\/T (rs929271) polymorphism\u3068\u3044\u3046\u306e\u3092\u30ab\u30c3\u30d7\u30eb\u304c\u6301\u3064\u5834\u5408\u3001\u7279\u306b\u598a\u5a20\u304c\u6210\u7acb\u3059\u308b\u78ba\u7387\u304c\u9ad8\u3044\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3057\u305f\u304c\u3001\u4eca\u56de\u306f\u4ed6\u306e\u591a\u578b\u3068\u6bd4\u3079\u3066\u3082\u9055\u3044\u304c\u7121\u3044\u3068\u3057\u3066\u3001\u5426\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br>\u80da\u7740\u5e8a\u7387\u3001\u81e8\u5e8a\u598a\u5a20\u7387\u3001\u6d41\u7523\u7387\u3001\u7d99\u7d9a\u598a\u5a20\u7387\u3059\u3079\u3066\u306b\u308f\u305f\u3063\u3066\u7d71\u8a08\u4e0a\u306e\u6709\u610f\u5dee\u304c\u793a\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br>LIF\u306e\u7740\u5e8a\u4e0d\u5168\u3078\u306e\u5fdc\u7528\u306f\u3001\u8ae6\u3081\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u306e\u3067\u3057\u3087\u3046\u304b\u3002 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