{"id":1996,"date":"2014-02-14T09:28:00","date_gmt":"2014-02-14T00:28:00","guid":{"rendered":"https:\/\/www.oakclinic-group.com\/blog\/?p=1996"},"modified":"2020-06-01T15:24:12","modified_gmt":"2020-06-01T06:24:12","slug":"taguchi01-65","status":"publish","type":"post","link":"https:\/\/www.oakclinic-group.com\/blog\/2014\/02\/14\/taguchi01-65\/","title":{"rendered":"\u51cd\u7d50\u6280\u8853"},"content":{"rendered":"\n

\u533b\u5e2b\u306e\u7530\u53e3\u65e9\u6850\u3067\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

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\u4ee5\u524d\u306f\u304c\u3093\u3084\u767d\u8840\u75c5\u306e\u8a3a\u65ad\u3092\u53d7\u3051\u308b\u3068\u305d\u306e\u75c5\u6c17\u306e\u6cbb\u7642\u3060\u3051\u3067\u7cbe\u4e00\u676f\u3067\u3001\u547d\u304c\u52a9\u304b\u308c\u3070\u3044\u3044\u3001\u3068\u3044\u3046\u98a8\u6f6e\u3067\u3057\u305f\u3002<\/p>\n\n\n\n

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Human Reproduction\uff08\u672c\u5e74\u4e00\u6708\u53f7\uff09\u306b\u3053\u3093\u306a\u8a18\u4e8b\u304c\u8f09\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death<\/p>\n\n\n\n

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\u7d50\u679c\u3001S1P\u3092\u6297\u304c\u3093\u5264\u3068\u4e00\u7dd2\u306b\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u3001\u6297\u304c\u3093\u5264\u306b\u3088\u308b\u5375\u5de3\uff08\u539f\u59cb\u5375\u80de\uff09\u3078\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u8efd\u6e1b\u3059\u308b\u52b9\u679c\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u6297\u304c\u3093\u5264\u3068\u3044\u3063\u3066\u3082\u3044\u308d\u3044\u308d\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u30a2\u30eb\u30ad\u30eb\u5316\u5264\u3068\u547c\u3070\u308c\u308b\u7a2e\u985e\u306e\u3001\u30b7\u30af\u30ed\u30d5\u30a9\u30b9\u30d5\u30a1\u30df\u30c9\u304c\u3068\u304f\u306b\u5375\u5de3\u6bd2\u6027\u304c\u5f37\u3044\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u6a5f\u5e8f\u306b\u3064\u3044\u3066\u306f\u7d50\u8ad6\u306b\u81f3\u3063\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u4eca\u56de\u306e\u8ad6\u6587\u3067\u306f\u3001\u7d30\u80de\u6b7b\u306e\u8a98\u5c0e\u306e\u7a0b\u5ea6\u304c\u6bd2\u6027\u3068\u3057\u3066\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\u4ed6\u8aac\u3067\u63a8\u6e2c\u8208\u5473\u6df1\u3044\u306e\u304c\u3001burnout\u3068\u3044\u3046\u73fe\u8c61\u3067\u3001\u539f\u59cb\u5375\u80de\u3092\u653b\u6483\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u672c\u6765\u9759\u6b62\u72b6\u614b\u306b\u3042\u308b\u306f\u305a\u306e\u539f\u5b50\u5375\u80de\u3092\u3069\u3093\u3069\u3093\u6d3b\u6027\u5316\u3057\u3066\u6d88\u8cbb\u3057\u3066\u3057\u307e\u3046\u304b\u3089\u3001\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n

*Sci Transl Med. <http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=ovary+burnout<\/a>>
2013 May 15;5(185):185ra62. doi: 10.1126\/scitranslmed.3005402.*<\/p>\n\n\n\n

*Cyclophosphamide triggers follicle activation and “burnout”; AS101
prevents follicle loss and preserves fertility*<\/p>\n\n\n\n

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