{"id":1377,"date":"2015-03-11T16:32:00","date_gmt":"2015-03-11T07:32:00","guid":{"rendered":"https:\/\/www.oakclinic-group.com\/blog\/?p=1377"},"modified":"2020-06-28T16:04:33","modified_gmt":"2020-06-28T07:04:33","slug":"funabiki01-19","status":"publish","type":"post","link":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/","title":{"rendered":"IGF-1\u3068\u7740\u5e8a\u7387\u306e\u95a2\u4fc2"},"content":{"rendered":"\n

\u533b\u5e2b\u306e\u8239\u66f3\u7f8e\u4e5f\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n

Insulin-like growth factor I increases apical fibronectin in blastocysts to increase blastocyst attachment to endometrial epithelial cells in vitro
Charmaine J.Green Australia Human Reproduction, Vol.30, No.2 pp.284-298,2015<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

\u67d3\u8272\u4f53\u6b63\u5e38\u80da\u3092\u79fb\u690d\u3057\u3066\u3082\u30011\u4eba\u76ee\u4e0d\u598a\u30682\u4eba\u76ee\u4e0d\u598a\u3067\u306f\u3001\u7d71\u8a08\u4e0a\u306f2\u4eba\u76ee\u306e\u307b\u3046\u304c\u598a\u5a20\u7387\u306f\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u5b50\u5bae\u306e\u7740\u5e8a\u7387\u306b\u500b\u4f53\u5dee\u304c\u3042\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n

\u7740\u5e8a\u306e\u904e\u7a0b\u306f\u3001
1\uff09\u5b50\u5bae\u5185\u819c\u7740\u5e8a\u7a93\uff08\u5b50\u5bae\u5185\u819c\u306e\u5909\u5316\uff09
2\uff09\u80da\u3068\u5b50\u5bae\u5185\u819c\u4e0a\u76ae\u306e\u63a5\u7740\u3000
3\uff09\u80da\u306e\u5b50\u5bae\u5185\u819c\u9593\u8cea\u3078\u306e\u6d78\u6f64
4\uff09\u8131\u843d\u819c\u5316\u3057\u305f\u5b50\u5bae\u5185\u819c\u9593\u8cea\u7d30\u80de\u3068\u306e\u80da\u306e\u76f8\u4e92\u4f5c\u7528
\u306e\u9806\u306b\u8d77\u3053\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

1\uff09\u306e\u7740\u5e8a\u7a93\u3068\u306f\u21d2\u3000\u53d7\u7cbe\u5f8c5\uff5e6 \u65e5\u76ee\u306b\u5b50\u5bae\u306b\u5230\u9054\u3057\u305f\u80da\u304c\u3001\u5b50\u5bae\u5185\u819c\u4e0a\u76ae\u306b\u5b8c\u5168\u306b\u304a\u304a\u308f\u308c\u308b12\u65e5\u76ee\u307e\u3067\u306b\u751f\u3058\u308b\u5185\u819c\u306e\u5909\u5316\u306e\u3053\u3068\u3092\u3044\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

2\uff09\u306e\u63a5\u7740\u3067\u306f\u21d2\u3000\u5b50\u5bae\u306b\u5230\u9054\u3057\u305f\u80da\u306f\u3001\u80da\u76e4\u80de\u306b\u306a\u308b\u3068\u3001\u305d\u306e\u5185\u7d30\u80de\u584a\uff08inner cell mass\uff09\u306epolar trophectoderm\u8868\u9762\u304c\u3001\u5b50\u5bae\u5185\u8154\u4e0a\u76ae\u7d30\u80de\u304c\u5411\u304b\u3044\u5408\u3046\u3088\u3046\u306b\u63a5\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u3068\u304d\u3001\u5b50\u5bae\u5185\u819c\u4e0a\u76ae\u8868\u9762\uff08apical surface\uff09\u306bpinopodes\u3068\u3044\u3046\u6a5f\u69cb\u304c\u51fa\u3066\u3001\u80da\u3068\u4e0a\u76ae\u306e\u63a5\u7740\u3092\u52a9\u3051\u307e\u3059\u3002<\/p>\n\n\n\n

\u305d\u3057\u3066\u3001\u80da\u306etrophoblast\u304a\u3088\u3073\u5b50\u5bae\u306e\u5185\u819c\u9593\u8cea\u7d30\u80de\u304b\u3089\u306f\u3001\u900f\u660e\u5e2f\u878d\u89e3\u9175\u7d20\u304c\u51fa\u3066\u3001\u80da\u306f\u900f\u660e\u5e2f\u3092\u8131\u51fa\uff1d\u5b75\u5316\uff08hatching\uff09\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

3\uff09\u306e\u6d78\u6f64\u3067\u306f\u21d2\u3000\u80da\u304c\u5b50\u5bae\u5185\u819c\u306b\u63a5\u7740\u3059\u308b\u3068\u3001\u80da\u306etrophoblast\u304c\u3001\u5404\u7a2eMMP(\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30d7\u30ed\u30c6\u30ca\u30fc\u30bc)\u3092\u7523\u751f\u3057\u3001\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\uff08\u7d44\u7e54\uff09\u3092\u5c40\u6240\u7684\u306b\u86cb\u767d\u878d\u89e3\u3057\u3001\u5b50\u5bae\u5185\u819c\u306b\u6d78\u6f64\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

4\uff09\u540c\u6642\u306b\u3001\u5206\u6ccc\u671f\u5b50\u5bae\u5185\u819c\u9593\u8cea\u7d30\u80de\u306f\u3001\u8840\u7ba1\u900f\u904e\u6027\u4ea2\u9032\u3001\u7740\u5e8a\u80da\u5468\u56f2\u306e\u8131\u843d\u819c\u5316\uff08decidualization\uff09\u3092\u751f\u3058\u307e\u3059\u3002
\u3053\u306e\u9593\u3001\u80da\u3068\u5185\u819c\u9593\u8cea\u7d30\u80de\u306f\u3001\u7740\u5e8a\u3092\u52a9\u3051\u308b\u305f\u3081\u3001\u80da\u304b\u3089\u306f\u7740\u5e8a\u3092\u4fc3\u3059\u7269\u8cea\u3092\u3001\u5185\u819c\u304b\u3089\u306f\u80da\u306e\u6210\u719f\u3092\u52a9\u3051\u308b\u7269\u8cea\u3092\u51fa\u3057\u3066\u3001\u76f8\u4e92\u306b\u4f5c\u7528\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u308c\u3089\u306e\u63a5\u7740\u7269\u8cea\u304c\u4f55\u304b\u3001\u4eca\u307e\u3067\u3082\u69d8\u3005\u306a\u7269\u8cea\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002
1\u3064\u306f\u3001\u80da\u76e4\u80de\u304b\u3089\u306ffibronectin\u3001\u5b50\u5bae\u5185\u819c\u304b\u3089\u306fintegrin\u3067\u3059\u3002\u4eca\u56de\u306f\u3001\u305d\u308c\u3089\u306e\u63a5\u7740\u56e0\u5b50\u304c\u3001IGF-1\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6210\u9577\u56e0\u5b50\uff09\u306b\u3088\u308a\u5897\u52a0\u3057\u305f\u3001\u3068\u3044\u3046\u8ad6\u6587\u3067\u3059\u3002<\/p>\n\n\n\n

\u3053\u306eIGF-1(insulin-like growth factor1)\u306f\u3001\u5b57\u306e\u3054\u3068\u304f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3068\u914d\u5217\u304c\u9ad8\u5ea6\u306b\u985e\u4f3c\u3057\u3066\u3044\u308b\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002\u6210\u9577\u30db\u30eb\u30e2\u30f3\u306e\u523a\u6fc0\u3092\u3046\u3051\u3001\u809d\u81d3\u3067\u5206\u6ccc\u3055\u308c\u307e\u3059\u3002\u7d30\u80de\u6210\u9577\u3068\u7d30\u80deDNA\u5408\u6210\u3092\u8abf\u6574\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u4eca\u56de\u306f\u30de\u30a6\u30b9\u3067\u306e\u5b9f\u9a13\u3067\u3059\u304c\u3001\u80da\u76e4\u80de\u306e\u57f9\u990a\u6db2\u306bIGF-1\u3092\u52a0\u3048\u308b\u3053\u3068\u306b\u3088\u308a\u3001
1\uff09\u80da\u76e4\u80de\u304c\u5185\u819c\u306b\u7740\u5e8a\u3059\u308b\u7387\u304c\u5897\u3048\u305f\u3002
2\uff09\u80da\u76e4\u80de\u304c\u7740\u5e8a\u3059\u308b\u3088\u3046\u306b\u6210\u9577\u3057\u305f\u3002
3\uff09\u80da\u76e4\u80de\u304c\u3001\u63a5\u7740\u56e0\u5b50\u306efibronectin\u306e\u5206\u6ccc\u3092\u5897\u3084\u3057\u305f\u3002\u5b50\u5bae\u5185\u819c\u304b\u3089\u3001\u63a5\u7740\u56e0\u5b50\u306eintegrin\u3092\u5897\u3084\u3059\u3067\u3042\u308d\u3046FAK\u306e\u5206\u6ccc\u304c\u5897\u3048\u305f\u3002<\/p>\n\n\n\n

\u3064\u307e\u308a\u3001\u57f9\u990a\u6db2\u306bIGF-1\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u3001\u7740\u5e8a\u7387\u304c\u3042\u304c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3001\u3068\u3044\u3046\u7d50\u8ad6\u3067\u3057\u305f\u3002\u3068\u3053\u308d\u3067\u3001\u751f\u4f53\u5185\u3067\u80da\u76e4\u80de\u306b\u306a\u308b\u306e\u306f\u3001\u5375\u7ba1\u30fb\u5b50\u5bae\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u5375\u7ba1\u3001\u5b50\u5bae\u5185\u3067IGF-1\u304c\u3075\u3048\u3066\u3044\u308c\u3070\u3088\u3044\u3002\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u5185\u81d3\u8102\u80aa\u3092\u6e1b\u91cf\u3059\u308b\u3053\u3068\u306b\u3088\u308aIGF-1\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u306a\u305c\u80a5\u6e80\u3067\u598a\u5a20\u7387\u304c\u3055\u304c\u308b\u306e\u304b\u3001\u30c0\u30a4\u30a8\u30c3\u30c8\u306b\u3088\u308a\u598a\u5a20\u7387\u304c\u6539\u5584\u3059\u308b\u306e\u304b\u3001\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u3053\u306eIGF-1\u306fkey\u306b\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u67d3\u8272\u4f53\u6b63\u5e38\u80da\u3092\u79fb\u690d\u3057\u3066\u3082\u30011\u4eba\u76ee\u4e0d\u598a\u30682\u4eba\u76ee\u4e0d\u598a\u3067\u306f\u3001\u7d71\u8a08\u4e0a\u306f2\u4eba\u76ee\u306e\u307b\u3046\u304c\u598a\u5a20\u7387\u306f\u9ad8\u3044\u3053\u3068\u304c\u2026<\/p>\n","protected":false},"author":1,"featured_media":1378,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"yoast_head":"\nIGF-1\u3068\u7740\u5e8a\u7387\u306e\u95a2\u4fc2 | \u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IGF-1\u3068\u7740\u5e8a\u7387\u306e\u95a2\u4fc2 | \u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0\" \/>\n<meta property=\"og:description\" content=\"\u67d3\u8272\u4f53\u6b63\u5e38\u80da\u3092\u79fb\u690d\u3057\u3066\u3082\u30011\u4eba\u76ee\u4e0d\u598a\u30682\u4eba\u76ee\u4e0d\u598a\u3067\u306f\u3001\u7d71\u8a08\u4e0a\u306f2\u4eba\u76ee\u306e\u307b\u3046\u304c\u598a\u5a20\u7387\u306f\u9ad8\u3044\u3053\u3068\u304c\u2026\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/\" \/>\n<meta property=\"og:site_name\" content=\"\u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/oakclinic1\" \/>\n<meta property=\"article:published_time\" content=\"2015-03-11T07:32:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-28T07:04:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2020\/03\/150311_funabiki.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"237\" \/>\n\t<meta property=\"og:image:height\" content=\"180\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u57f7\u7b46\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin_oak\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/#organization\",\"name\":\"\u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\",\"url\":\"https:\/\/www.oakclinic-group.com\/blog\/\",\"sameAs\":[\"https:\/\/www.facebook.com\/oakclinic1\"],\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2025\/03\/\u30ed\u30b4.png\",\"contentUrl\":\"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2025\/03\/\u30ed\u30b4.png\",\"width\":207,\"height\":81,\"caption\":\"\u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\"},\"image\":{\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/#\/schema\/logo\/image\/\"}},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/#website\",\"url\":\"https:\/\/www.oakclinic-group.com\/blog\/\",\"name\":\"\u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0\",\"description\":\"\u751f\u6b96\u533b\u7642\u306e\u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u3001\u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u306e\u4e0d\u598a\u30d6\u30ed\u30b0\u3067\u3059\u3002\",\"publisher\":{\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.oakclinic-group.com\/blog\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"ja\"},{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#primaryimage\",\"url\":\"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2020\/03\/150311_funabiki.jpg\",\"contentUrl\":\"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2020\/03\/150311_funabiki.jpg\",\"width\":237,\"height\":180},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#webpage\",\"url\":\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/\",\"name\":\"IGF-1\u3068\u7740\u5e8a\u7387\u306e\u95a2\u4fc2 | \u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0\",\"isPartOf\":{\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#primaryimage\"},\"datePublished\":\"2015-03-11T07:32:00+00:00\",\"dateModified\":\"2020-06-28T07:04:33+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u30db\u30fc\u30e0\",\"item\":\"https:\/\/www.oakclinic-group.com\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"IGF-1\u3068\u7740\u5e8a\u7387\u306e\u95a2\u4fc2\"}]},{\"@type\":\"Article\",\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#webpage\"},\"author\":{\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/#\/schema\/person\/074b89e0f97a12cf864fc601a6cf7d63\"},\"headline\":\"IGF-1\u3068\u7740\u5e8a\u7387\u306e\u95a2\u4fc2\",\"datePublished\":\"2015-03-11T07:32:00+00:00\",\"dateModified\":\"2020-06-28T07:04:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#webpage\"},\"wordCount\":59,\"publisher\":{\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2020\/03\/150311_funabiki.jpg\",\"articleSection\":[\"\u8239\u66f3\u7f8e\u4e5f\u5b50\"],\"inLanguage\":\"ja\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.oakclinic-group.com\/blog\/#\/schema\/person\/074b89e0f97a12cf864fc601a6cf7d63\",\"name\":\"admin_oak\",\"url\":\"https:\/\/www.oakclinic-group.com\/blog\/author\/admin_oak\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"IGF-1\u3068\u7740\u5e8a\u7387\u306e\u95a2\u4fc2 | \u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/","og_locale":"ja_JP","og_type":"article","og_title":"IGF-1\u3068\u7740\u5e8a\u7387\u306e\u95a2\u4fc2 | \u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0","og_description":"\u67d3\u8272\u4f53\u6b63\u5e38\u80da\u3092\u79fb\u690d\u3057\u3066\u3082\u30011\u4eba\u76ee\u4e0d\u598a\u30682\u4eba\u76ee\u4e0d\u598a\u3067\u306f\u3001\u7d71\u8a08\u4e0a\u306f2\u4eba\u76ee\u306e\u307b\u3046\u304c\u598a\u5a20\u7387\u306f\u9ad8\u3044\u3053\u3068\u304c\u2026","og_url":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/","og_site_name":"\u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0","article_publisher":"https:\/\/www.facebook.com\/oakclinic1","article_published_time":"2015-03-11T07:32:00+00:00","article_modified_time":"2020-06-28T07:04:33+00:00","og_image":[{"width":237,"height":180,"url":"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2020\/03\/150311_funabiki.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"\u57f7\u7b46\u8005":"admin_oak"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Organization","@id":"https:\/\/www.oakclinic-group.com\/blog\/#organization","name":"\u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a","url":"https:\/\/www.oakclinic-group.com\/blog\/","sameAs":["https:\/\/www.facebook.com\/oakclinic1"],"logo":{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/www.oakclinic-group.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2025\/03\/\u30ed\u30b4.png","contentUrl":"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2025\/03\/\u30ed\u30b4.png","width":207,"height":81,"caption":"\u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a"},"image":{"@id":"https:\/\/www.oakclinic-group.com\/blog\/#\/schema\/logo\/image\/"}},{"@type":"WebSite","@id":"https:\/\/www.oakclinic-group.com\/blog\/#website","url":"https:\/\/www.oakclinic-group.com\/blog\/","name":"\u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0","description":"\u751f\u6b96\u533b\u7642\u306e\u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u3001\u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u306e\u4e0d\u598a\u30d6\u30ed\u30b0\u3067\u3059\u3002","publisher":{"@id":"https:\/\/www.oakclinic-group.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.oakclinic-group.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"ja"},{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#primaryimage","url":"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2020\/03\/150311_funabiki.jpg","contentUrl":"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2020\/03\/150311_funabiki.jpg","width":237,"height":180},{"@type":"WebPage","@id":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#webpage","url":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/","name":"IGF-1\u3068\u7740\u5e8a\u7387\u306e\u95a2\u4fc2 | \u533b\u7642\u6cd5\u4eba\u30aa\u30fc\u30af\u4f1a\u3000\u4e0d\u598a\u30d6\u30ed\u30b0","isPartOf":{"@id":"https:\/\/www.oakclinic-group.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#primaryimage"},"datePublished":"2015-03-11T07:32:00+00:00","dateModified":"2020-06-28T07:04:33+00:00","breadcrumb":{"@id":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u30db\u30fc\u30e0","item":"https:\/\/www.oakclinic-group.com\/blog\/"},{"@type":"ListItem","position":2,"name":"IGF-1\u3068\u7740\u5e8a\u7387\u306e\u95a2\u4fc2"}]},{"@type":"Article","@id":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#article","isPartOf":{"@id":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#webpage"},"author":{"@id":"https:\/\/www.oakclinic-group.com\/blog\/#\/schema\/person\/074b89e0f97a12cf864fc601a6cf7d63"},"headline":"IGF-1\u3068\u7740\u5e8a\u7387\u306e\u95a2\u4fc2","datePublished":"2015-03-11T07:32:00+00:00","dateModified":"2020-06-28T07:04:33+00:00","mainEntityOfPage":{"@id":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#webpage"},"wordCount":59,"publisher":{"@id":"https:\/\/www.oakclinic-group.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.oakclinic-group.com\/blog\/2015\/03\/11\/funabiki01-19\/#primaryimage"},"thumbnailUrl":"https:\/\/www.oakclinic-group.com\/blog\/wp-content\/uploads\/2020\/03\/150311_funabiki.jpg","articleSection":["\u8239\u66f3\u7f8e\u4e5f\u5b50"],"inLanguage":"ja"},{"@type":"Person","@id":"https:\/\/www.oakclinic-group.com\/blog\/#\/schema\/person\/074b89e0f97a12cf864fc601a6cf7d63","name":"admin_oak","url":"https:\/\/www.oakclinic-group.com\/blog\/author\/admin_oak\/"}]}},"_links":{"self":[{"href":"https:\/\/www.oakclinic-group.com\/blog\/wp-json\/wp\/v2\/posts\/1377"}],"collection":[{"href":"https:\/\/www.oakclinic-group.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.oakclinic-group.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.oakclinic-group.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.oakclinic-group.com\/blog\/wp-json\/wp\/v2\/comments?post=1377"}],"version-history":[{"count":4,"href":"https:\/\/www.oakclinic-group.com\/blog\/wp-json\/wp\/v2\/posts\/1377\/revisions"}],"predecessor-version":[{"id":4975,"href":"https:\/\/www.oakclinic-group.com\/blog\/wp-json\/wp\/v2\/posts\/1377\/revisions\/4975"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.oakclinic-group.com\/blog\/wp-json\/wp\/v2\/media\/1378"}],"wp:attachment":[{"href":"https:\/\/www.oakclinic-group.com\/blog\/wp-json\/wp\/v2\/media?parent=1377"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.oakclinic-group.com\/blog\/wp-json\/wp\/v2\/categories?post=1377"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.oakclinic-group.com\/blog\/wp-json\/wp\/v2\/tags?post=1377"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}