|Other Approaches to the Endometrium|
・ There are many reports that an endometrial thickness of 7 mm or more is required for embryo implantation. Intrauterine administration of granulocyte colony stimulating factor (G-CSF) is treatment for a thin endometrium. G-CSF preparation is an approved injectable drug (granulocyte increasing action), and it is widely used for routine medical treatment. It was reported that G-CSF in the uterine lumen improved the endometrium thickness and the pregnancy rate improved significantly for infertile women with a thin endometrium prior to embryo transplantation (Gleicher N, et al., Fertility and Sterility 2011; 95: 2123.e13-e17.). For patients who have a thin endometrium by conventional methods, G-CSF is administered into the uterine cavity after informed consent.
・ Intrauterine administration of human chorionic gonadotropin (HCG)
An improvement in pregnancy performance by injecting a small amount of HCG into the uterus just before an embryo transfer has been reported (Mansour R, et al., Fertility and Sterility 2011; 96: 1370-1374.e1.). You may receive this by request.