Pioneer of infertility treatment. Covering the needs of infertility from various tests 
to IVF/ICSI’s Advanced Reproductive Technologies.

〔Sumiyoshi&Ginza〕Artificial Hatching Assistance(AHA)

This is the skill used to open a hole in the zona pellucida of the blastocyst and or embryo that is to be transplanted.

To break the zona pellucida and the cell coming out is called “hatching”, and when the cell that comes out is attached to the endometrium pregnancy is achieved.  Regularly after fertilization they will naturally hatch around the fifth to sixth day, but there are situations when the zona pellucida has hardened, or the blastocyst’s power itself will not hatch.  What works for these cases is AHA.  There is the method of dissolving the zona pellucida with the medicine called acidic tyrode, the method of opening hole by poking it with a needle and causing friction with a glass tool, and there are handful of others, but recently by use of laser has become the mainstream method.

 

 

The blastocyst at Day 5-6 after
fertilization Enlarged,
the zona pellucida is thinning.

The blastocyst at Day 5-6 after
fertilization Enlarged,
the zona pellucida is thinning.

Hatched blastocyst

Hatched blastocyst


 

 

Zona pellucida Aperture Method

 

Zona pellucida Thinning Method

 

 

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Oak Medical Group has been from the time we opened, supporting the many issues of women's health, building performance and trust, and not only here in Osaka, but centering in Kansai we are receiving patients from across Japan.
Especially with our infertility treatment, we are widely covering the various tests to IVF/ICSI's Advanced Reproductive Technologies.  Depending on the cause of the infertility, we are handling the treatment of each patient one by one.  If you have some concerns, please don't hesitate to consult with us.